One possible plotline could be her journey to overcome her blindness and prove herself as a ninja. She might have to develop her other senses more acutely, like hearing and smell, to compensate for her lack of sight. For example, she could learn to sense chakra in a different way.
Another plot could revolve around how she is treated by the other villagers. Some might underestimate her because of her blindness, but she could surprise them with her determination and unique skills. Maybe she forms a special bond with a mentor who helps her train and see past her disability. It could also involve her participation in important ninja missions where her blindness becomes both a challenge and an advantage in unexpected ways.
Perhaps the story could focus on her discovery of a hidden power within herself that is related to her blindness. It could be a power that only she has because of her unique situation. She might then have to learn how to control and use this power while also dealing with the regular challenges of being a ninja in the Naruto universe. There could be a sub - plot about her relationships with other characters like Sasuke or Sakura, and how they view her new - found power and her as a person.