Sure. There are some great ones out there. One aspect that makes a good 'serious Naruto x fem Sasuke' fanfiction is the depth of the characters. The authors often delve into how a female Sasuke would handle her clan's situation differently. In some fanfictions, Naruto's unwavering determination to reach out to Sasuke, whether male or female, is a central theme. It's all about finding the ones that really capture the essence of their relationship in a new and interesting light.
Yes, there are quite a few. You can start by looking on fanfiction platforms like FanFiction.net or Archive of Our Own. Just search for 'serious Naruto x fem Sasuke' and you'll find a variety of stories. Some might focus on their relationship development in an alternate universe where Sasuke is female, exploring how their interactions change while still maintaining the essence of their characters from the original Naruto series.