Perhaps there are demons or dark forces that are trying to disrupt the union between Bella and the God of War. These antagonists could be bent on causing chaos and destruction in their world, seeing their relationship as a symbol of hope that they want to destroy.
Often, the Volturi can be antagonists. They might not approve of Jasper and Bella's relationship for some reason, like they think it goes against vampire laws or traditions. Another possible antagonist could be a rogue vampire who has a vendetta against the Cullens and sees Jasper and Bella's relationship as a way to get to them.
Sometimes, other werewolves who don't accept Bella as Jacob's mate could be the antagonists. They might think that a human - werewolf relationship goes against their pack's rules or beliefs.
Often, other vampires or supernatural creatures could be the main antagonists. For example, vampires who are jealous of Damon's newfound mate might try to drive a wedge between them. Maybe there are some werewolves who see Bella as a threat to their territory because of her relationship with Damon.
Often, the Volturi can be antagonists. They have strict rules about vampire relationships and activities. If Bella and Jasper's relationship goes against their laws, the Volturi would oppose it. They might see it as a disruption to the vampire order they uphold.
In God of War 1, the main antagonist is Ares. In God of War 2 and 3, Zeus is the main antagonist as he betrays Kratos and tries to stop him from getting revenge.
It could be the traditional God of War villains like the gods who oppose Izuku. Maybe Ares, if he's still around in the fanfiction's version of the God of War world, would see Izuku as a threat and try to stop him.
There could be an ancient evil force that awakens because of Luffy's new powers. This force was once sealed away but now wants to destroy Luffy and everything he stands for, seeing him as a disruption to the balance it once knew.
Well, it could be about Bella having to face many challenges as the mate of the God of War. Maybe she has to learn combat skills or deal with the jealousy of other characters in that fictional world.
Another possible antagonist could be some of the more bloodthirsty and power - hungry warlords or demons in the God of War universe. They might not care about Percy's origin or his powers, but simply see him as someone to be defeated or enslaved. These types of characters are often driven by pure greed and a desire for chaos, which would put them directly in Percy's path.
It could be the Titans who escaped from Tartarus and are seeking revenge. They might see Percy and Apollo's relationship as a threat to their plans of overthrowing the Olympians. Another possibility is some jealous gods or goddesses who don't like the idea of Percy and Apollo being mates.