Some of his other friends like Tracey might be really taken aback. He would have to re - adjust his perception of Ash. Serena, if she's in the story, might have a complex reaction. She could be envious in a way but also feel a stronger connection to Ash in his female form as they can now share more 'female - centric' experiences. And his rivals like Gary might initially make fun of him but later realize that Ash is still the same strong trainer despite the physical change.
His best friend Pikachu might be a bit confused at first but would quickly adapt as it still senses Ash's essence. Brock would probably be very surprised and might offer some comical comments or advice on how to handle the new situation. Misty could be a mix of shocked and intrigued. She might be a bit jealous of Ash's new female appearance at first, but then would support him as they are friends.
One possible plot could be that a spell or a magical artifact causes Ash to turn into a girl. Ericka might be involved in the discovery of this transformation. Ash then has to deal with the new physical form while still trying to pursue his Pokemon journey. His Pokemon might initially be confused but still recognize him. And he could face different challenges and reactions from his friends and rivals as a girl.
At first, his friends would be in disbelief. But then, they would start to adapt. Dawn might see it as an opportunity to study a Pokémon from a different perspective. Gary could be both amused and intrigued, and might offer some scientific theories on how it happened. Overall, they would all be concerned for Ash's well - being and work together to either help him get back to normal or help him thrive in his new form.
His friends would be very shocked at first. Misty might be a bit worried and try to find a way to turn him back quickly. Brock, on the other hand, would be more curious and start observing Ash - as - Pikachu to see how his behavior has changed. His Pokémon friends would also be confused. Pikachu himself might be both excited to have a 'Pikachu - like' friend but also a bit sad that his trainer is in this strange state.
His friends' reactions would be mixed. Shikamaru would be like 'This is such a drag.' But he'd also start thinking of strategies to deal with the situation. Ino would be all about helping Naruto with his new look, like suggesting new outfits that would suit a fox girl. Choji would be more focused on making sure Naruto is still the same person inside. He'd offer Naruto his snacks to cheer him up. And Hinata would be blushing a lot, but also be very supportive, saying things like 'Naruto - kun, you look... different, but you're still you.'
Sakura might be initially shocked and a bit jealous at how cute Naruto - as - a - girl is. Sasuke would probably be confused at first but then act indifferent. Kakashi would be his usual calm self, but might crack a few jokes about Naruto's new look.
His best friend, Gwen, might be initially shocked but then would be very supportive. She could help Ben understand the new social dynamics that come with being a girl. Kevin, on the other hand, might be a bit more awkward at first. He's used to the rough - and - tumble Ben, and this new form might throw him off. But eventually, he would come around and still see Ben as his friend and ally in fighting bad guys.
At first, his Pokémon would be startled. They've always known Ash as a human. But then, they would start to adapt. Some Pokémon, like Squirtle, might try to play with Ash in his new form, thinking it's a new kind of game. However, his more loyal Pokémon, like Greninja, would be determined to find a way to turn Ash back. Greninja might use its special bond with Ash to try and communicate with him on a deeper level in this new form, to understand what happened and how to reverse it.
His other Pokémon like Charizard would be completely bewildered. Charizard might initially think that this Eevee is just some random Pokémon near its territory. But when it senses something familiar about the Eevee, it would be hesitant and curious. It could try to communicate in its own way, like using small bursts of fire to get the Eevee's (Ash's) attention. The Pokémon that Ash has a closer bond with would be more determined to figure out what's going on and how to help him.
I think his friends' reactions would vary. Naruto's closest friends like Shikamaru and Kiba would quickly realize that they need to support Naruto. They would see that despite the strange new form, it's still Naruto. Sakura would be more emotional, she might cry at first but then pull herself together to help. And Sasuke, he would probably see it as an opportunity for Naruto to gain more power, but also be cautious in case the Titan form has any negative effects on Naruto's mind.
His friends would be extremely shocked at first. Misty might scream and be really confused about what's happening to Ash. Brock, on the other hand, would probably try to stay calm and start thinking of ways to reverse the transformation right away. They would all be worried about how Ash is feeling in his new form and if he's in any pain. They would also be concerned about how they can still communicate with him effectively, since he's becoming a Pokemon.