Well, it could be about Ranma getting transferred to the Highschool DxD world. Maybe he'd get involved in the supernatural battles there, using his martial arts skills. He might team up with Issei and the others, and his unique curse could add an interesting twist to the story. For example, his transformation between male and female forms could lead to some comical or strategic situations during fights.
A third idea is that there's a mix - up with the curses in both worlds. Ranma's curse of changing into a girl when splashed with cold water gets combined with some of the magic in Highschool DxD. This creates a whole new set of problems and adventures for him as he tries to figure out how to deal with this strange new situation while also trying to keep his identity a secret from the new characters he meets.
The plot could involve Ben's aliens having an unexpected effect on the magic in the Highschool DxD world. His alien DNA might interact with the devil or angel powers in strange ways. For instance, if he transformed into Heatblast near a magic spell, it could cause the spell to go haywire. And his presence could also disrupt the power balance between the different factions in the DxD world, leading to new alliances and rivalries.
Ranma would probably be very confused at first when he enters the Highschool DxD world. He might be skeptical of the devils and angels. Issei, being a pervert, might be really interested in Ranma's female form. But Ranma would likely not tolerate Issei's behavior easily. Kuno from Ranma 1/2 might see the DxD characters as new rivals for Ranma's affections. And the female characters from DxD could be intrigued by Ranma's martial arts skills and his tough - yet sometimes clumsy - personality.
A plot could revolve around a spell gone wrong that merges the two worlds partially. Saber finds herself in a strange new world filled with devils, angels, and fallen angels. She might initially be confused but quickly adapt. Her presence could disrupt the balance of power in Highschool DxD. For example, the devils might see her as a threat or an opportunity to gain more power. And Saber would have to navigate this new world while trying to find a way back to her own world.
The most interesting plot could be one where Ranma and Issei swap bodies. Issei would have to deal with Ranma's martial arts world and his curse, while Ranma would have to handle Issei's life as a perverted devil. This would lead to a lot of comical misunderstandings and also some deep character development as they both learn from each other's experiences and try to get back to their original bodies.
One possible interesting plot could be Sasuke arriving in the Highschool DxD world during a time of chaos. Maybe there's a new threat that neither the devils nor the other factions can handle easily. Sasuke's ninja skills and Sharingan would give him an edge in combat. He could form an alliance with Issei and his group, teaching them some ninja techniques in return for learning about the supernatural powers in their world.
Well, a cool plot might involve Issei from Highschool DxD being sent to the Naruto world. He could learn ninjutsu there and then bring some of those skills back to his own world. He might befriend Naruto and they could work together to fight a common enemy that has somehow crossed between the two worlds, like an evil group that wants to take over both the ninja world and the world of devils and angels.
The plot could involve a group of Star Wars characters finding their way into the Highschool DxD world. For example, a Jedi and a Sith could end up at the school. The students at the school would be both fascinated and confused by their lightsabers and the Force abilities. And the Star Wars characters would have to deal with the devils, angels and other supernatural beings in the DxD world. There could be battles where the Jedi's lightsaber skills are pitted against the devil's powers, and alliances could be formed in the most unexpected ways.
One possible plot could be that Ichigo somehow gets transported to the world of High School DxD. He might initially be seen as a threat by the devils and angels there due to his unknown powers. But as they learn about his motives of protecting people, they start to work with him. Ichigo could also teach the characters in High School DxD about his unique fighting style and the concept of Hollow and Soul Reaper powers, leading to new and exciting battles against common enemies.
Well, the plot could involve a character from Highschool DxD making a deal that accidentally summons the Ghost Rider. The Rider then starts to hunt down evil in the Highschool DxD world, which includes some of the more malevolent devils and fallen angels. This would force the different factions in Highschool DxD to either side with the Ghost Rider or oppose him. And the main character of Highschool DxD might be caught in the middle, trying to figure out how to deal with this new and extremely powerful entity.