The plot could center around Sakura's role in Itachi's decision - making. Since she's his older sister, she has a certain influence over him. Maybe she has a different view on the Uchiha's situation compared to the elders in the clan. She could be the voice of reason for Itachi, guiding him to find a more peaceful solution to the clan's problems. For example, she could encourage Itachi to negotiate with the village leaders instead of following the orders blindly. And in the process, her relationship with Itachi would be explored deeply, showing their bond as siblings.
A really interesting plot might be that Sakura, as Itachi's sister, has been secretly protected by Itachi all along. When Itachi dies, she sets out on a journey to understand her brother better. Along the way, she uncovers secrets about their family and the Uchiha clan that no one else knew. This could lead to her becoming a key figure in mending the relationship between the remaining Uchiha and the rest of Konoha.
One plot idea could be that Sakura discovers her relation to Deidara later in life. This could lead to a conflict within herself as she has to reconcile her loyalty to her friends in Konoha with her new - found family connection to a former enemy. Another idea is that Deidara, knowing she is his sister, tries to protect her during battles without revealing their relationship at first.
One possible plot could be that Sakura discovers Itachi sleeping in an unexpected place, like a hidden grove. She is initially startled but then becomes curious. As she watches him sleep, she might notice his peaceful expression and start to think about how complex he is as a person. She could then decide to stay and protect his resting place until he wakes up, leading to a conversation where they exchange views on life and the ninja world when he wakes.
One possible plot could be that Sakura, eager to improve her skills, seeks out Itachi. Itachi, seeing her determination, decides to train her in the ways of genjutsu. He starts with the basics, teaching her how to detect and break simple genjutsu. Sakura, being a fast learner, quickly grasps the concepts. As the training progresses, they face challenges together, like dealing with rogue ninjas who try to disrupt their training. This not only tests Sakura's newfound skills but also deepens the bond between her and Itachi.
Well, perhaps the plot could involve Sakura being assigned as Itachi's secretary in a powerful ninja organization. At first, Itachi is cold and distant towards her, but Sakura is determined to do her job well. As time passes, they start to have mutual respect for each other's skills. Then, an external threat to the organization emerges, and Sakura and Itachi have to work together closely, which leads to a deeper understanding and maybe even the start of a romantic relationship between them.
Perhaps in the fanfiction, Sakura and Itachi are in a police force that has to deal with international ninja disputes. Sakura, with her intelligence and strong will, and Itachi, with his strategic mind, work together to prevent a full - scale war between two large ninja clans. They face many challenges along the way, including distrust from their own comrades who are skeptical of their unorthodox methods.
The plot could involve Itachi noticing Sakura's isolation within her own team at some point. He decides to adopt her in a sense, like becoming a mentor to her. Itachi could share his insights on how to deal with powerful enemies and the sacrifices one has to make for the greater good. Sakura would then grow not only in her combat skills but also in her understanding of the complex world of ninjas. She might start to see things from a different perspective, similar to Itachi's, which could cause some friction and also growth within her relationships with Naruto and Sasuke.
One possible plot could be that Itachi and Shisui are on a mission in the ANBU and they cross paths with Sakura who is also on a mission related to a medical emergency in a war - torn area. They initially have some misunderstandings as Sakura is not used to the ANBU's way of doing things, but eventually they work together. Itachi and Shisui use their combat skills while Sakura uses her medical ninjutsu to save a village from a hidden enemy's attack.
Perhaps in the fanfiction, the first time is when Sakura is sent to spy on Itachi. But instead of hating him as she expected, she discovers a side of Itachi that is full of pain and regret. This changes her perception of him completely and she decides to try and help him, leading to a complex relationship between them.
One plot idea could be that Itachi and Shisui are on a mission and they cross paths with Sakura. Shisui, being the friendly one, starts to teach Sakura some new jutsu skills. Itachi, initially reluctant, gradually warms up to Sakura's determination. Another could be a time - travel plot where Sakura goes back in time and meets a young Itachi and Shisui. She tries to prevent some of the tragedies that are to befall them in the future. And finally, a plot where Itachi and Shisui are in a life - or - death situation and Sakura, with her medical skills, has to save them and in the process, they form a strong bond.