Well, a great plot might involve Bill Cipher from Gravity Falls making a deal with a crossroads demon in Supernatural. This could lead to a chaotic situation where the rules of both universes start to blend. For example, the symbols and spells in Supernatural might start to have an effect on the Gravity Falls' magical creatures, and vice versa.
One of the most interesting plot twists could be when the characters from Gravity Falls and Reverse Falls have to team up against a common enemy they didn't expect. For example, a new supernatural force that threatens both their worlds. This would force them to put aside their differences and work together, which is a big change considering the nature of the two settings.
A really cool storyline might involve a powerful object or spell that links the two shows. For instance, a magical artifact in 'Supernatural' that can also affect the Wesen in 'Grimm'. The characters from both shows would have to race against time to find and control this object before it falls into the wrong hands. It would be a high - stakes adventure that combines the best elements of both shows, like the family - centered themes in 'Supernatural' and the unique fairy - tale inspired world of 'Grimm'.
Bill Cipher would be a major wildcard in their interactions. If he were to cross paths with the Winchesters, he would likely try to manipulate them for his own amusement. He might offer them false information or try to pit them against the other characters in Gravity Falls. The Winchesters, being used to dealing with devious creatures, would have to be on their guard and figure out a way to outwit Bill while also trying to solve whatever mystery has brought them to Gravity Falls in the first place.
A great storyline might involve a fusion of the two worlds' mechanics. For example, the Velvet Room from Persona could have some connection to Joker's world. The Igor-like figure could offer Joker and his friends some new kind of power or knowledge that they use to combat a common foe. Or perhaps the Persona characters learn about Joker's Metaverse Navigator and try to replicate it in their world, which leads to all sorts of unforeseen consequences and adventures.
One interesting plot could be the characters from Gravity Falls getting involved in the Voltron universe's battles. Maybe Dipper and Mabel accidentally stumble into the world of Voltron while on one of their mystery hunts. They could use their unique skills, like Dipper's knowledge of the supernatural and Mabel's out - of - the - box thinking, to help the Voltron team in unexpected ways.
A crossover involving a shared enemy. Maybe a new alien race that is a threat to both universes emerges. The combined forces of Babylon 5 and Star Trek would have to pool their resources. The Starfleet officers could share their scientific knowledge to analyze the new threat, while the Babylon 5 personnel could offer their street - smart combat and negotiation skills developed from their own experiences in the often - tumultuous Babylon 5 station.
Well, perhaps a story where the two characters cross paths due to a serial killer case. The killer seems to be targeting people involved in the legal system, and Perry Mason is representing some of the potential victims or suspects. Ironside gets involved as the detective on the case. Their different approaches at first clash but then they start to respect each other and combine their efforts to catch the killer. They might also discover a hidden conspiracy behind the killings.
A crossover fanfiction could also explore a personal connection. What if a member of the Reagan family was a big fan of Castle's books? And then they end up meeting in a situation where they need to work together on a case. This would add an interesting layer of fan - meets - idol dynamic to the story while also dealing with the crime - solving aspect.
One of the most interesting storylines could be about a character from Skyrim finding themselves in the world of Dragon Age. Maybe a Dragonborn suddenly appears in Ferelden during the Blight. They could use their Thu'um to fight darkspawn in a way that astonishes the people there. Another great idea is a mage from Dragon Age being teleported to Skyrim and having to deal with the different magic system and dragons there.
One interesting storyline could be the interaction between the angels and demons from Good Omens and Lucifer. Maybe the characters from Good Omens end up in Lucifer's LA and have to deal with his brand of chaos. It could lead to some really funny and thought - provoking situations as they compare their different views on good and evil.