In some extreme or non - canon fanfictions, this might happen. One possible reason could be if she was under some sort of mind - control. For example, a villain might use a dark - type Pokemon's power to control her actions and make her do things that she wouldn't normally do, like hurting Ash. Another reason could be a misunderstanding. Maybe she thought Ash was in danger of being corrupted by a powerful and evil Pokemon, and in her attempt to'save' him, she ended up hurting him accidentally.
Yes, there might be such fanfictions. In a possible scenario, she could be forced to hurt Ash because of a blackmail situation. Some evil organization could have threatened to harm other people she cares about if she didn't follow their orders to harm Ash. Or perhaps there was a prophecy that stated Ash would bring great destruction, and she, in a desperate attempt to prevent this prophecy from coming true, thought she had to hurt him to stop him from continuing his Pokemon journey.
One possible reason could be jealousy. Maybe Ash has achieved more in his Pokemon journey than his friends, and they can't handle it. Another reason might be some misunderstanding. For example, an enemy could trick Ash's friends into thinking Ash has done something bad. Or perhaps there's some sort of power struggle. If there's a powerful item or a rare Pokemon involved, and Ash is the main contender, his friends might be tempted to betray him for their own gain.
It could also be due to competition. Sabrina might see Ash as a threat to her status as a powerful trainer. If Ash starts to gain more recognition and success, Sabrina, being prideful, could feel betrayed as if Ash is trying to overshadow her and thus take actions against him.
One reason could be a powerful and evil Pokémon that he couldn't defeat. Maybe he encounters a super - strong legendary Pokémon that has been corrupted or is in a rage and it ends up fatally injuring him. Another possibility is that he sacrifices himself to save his friends or his Pokémon. For example, he might put himself in harm's way to protect Pikachu from a dangerous situation.
One reason could be a sense of over - whelming responsibility. If Ash has too many Pokemon to care for in the fanfic, he might feel he can't give each one proper attention and thus abandons some. Another possibility is if a particular Pokemon has some sort of 'dark side' or uncontrollable power that Ash fears he can't handle, leading to abandonment.
Betrayal could also stem from a misunderstanding. Maybe Ash or Cynthia accidentally offend someone without realizing it. For example, they might unknowingly step on a trainer's dreams or beliefs. And that trainer, feeling deeply hurt, decides to betray them. Or it could be that a Pokemon they both have a connection with has a different loyalty that they were not aware of, which leads to the Pokemon causing their betrayal.
One reason could be power. Maybe he was offered a great deal of power by an outside force in exchange for betraying the harem. Another could be jealousy. If there was someone in the harem who was getting more attention or was more successful than him in some way, he might have been driven by envy to betray them.
It could be due to a misunderstanding of local customs. Ash travels to many different places. In some fanfictions, he could end up in a village or town where the local laws or traditions demand that he wears a dress for a specific reason. For example, he might be mistaken for someone else who is required to wear a dress as a form of punishment or celebration.
One possible reason could be the trauma Peeta has endured in the Hunger Games. His flashbacks might make him confused and unable to distinguish between reality and the cruel world of the Games. So, he accidentally hurts Katniss.
Another possibility is that there was some sort of conspiracy against her. In fanfiction, there could be other characters who are jealous of Serena's success. They might frame her for something she didn't do, like planting evidence that she cheated in some way. So, the false accusations could result in her disqualification.
Perhaps she's under the influence of a powerful genjutsu. Genjutsu can distort one's perception and make them do things they wouldn't normally do. In this case, Kushina might be seeing Naruto as an enemy in the genjutsu and thus hurt him. Or it could be a test in a very extreme way. She might think that by putting Naruto through pain, she can make him stronger, although this is a very cruel way of thinking.