Sakura might be initially hostile towards Kisame, given his reputation as an Akatsuki member. She would probably attack or be on guard. But Kisame, with his calm and somewhat menacing demeanor, would likely try to taunt her at first. For example, he could say things like 'Little girl, you think you can take on the likes of me?' However, as the story progresses, if they are forced to be around each other, they could develop a begrudging respect. Sakura might respect Kisame's strength, and Kisame could come to respect Sakura's tenacity.
In a fanfiction, Sakura could use her intelligence and medical skills to help Inuyasha when he gets injured. Inuyasha would be impressed by her ability to heal, which is different from Kagome's spiritual powers. They might also argue a lot, as Sakura is used to a more structured ninja world and Inuyasha is a wild half - demon. But through these interactions, they could grow to respect and even like each other.
They could interact in a more intellectual way as well. Sakura, with her knowledge from the future, could introduce new concepts about medical ninjutsu and chakra theory to Tobirama. He, in turn, could share with her the secrets of some of the older jutsus that have been lost in her time. Their conversations would be a blend of mutual learning and challenging each other's ideas.
Sakura might be quite assertive in her interactions. She could challenge Kisame's views on things like school rules or the importance of certain subjects. For example, if Kisame thinks physical education is the most important, Sakura might argue for the value of academic studies. And Kisame would probably respond with his gruff yet somewhat respectful attitude, listening to her points even if he doesn't fully agree at first.
Sakura is a very intelligent and hard - working character. Hashirama is creative and has a great sense of leadership. In a fanfiction, their personalities could create an interesting dynamic. Sakura would likely ask Hashirama a lot of questions about the old ways of the ninja world, and Hashirama would be eager to answer. Their interactions could also lead to new ideas for both of them. For example, Sakura could come up with a new way to use her medical ninjutsu in combat based on Hashirama's combat strategies, and Hashirama could think of new ways to improve the village's medical facilities based on Sakura's knowledge.
They could interact through Naruto. Since Naruto is the host of Kurama, Sakura could communicate with Kurama via Naruto. For example, when Naruto is unconscious after a tough battle, Sakura could try to reach Kurama to find a way to heal Naruto.
One possible plot could be that Sakura, on a mission in a far - off land, encounters Kisame. At first, they are enemies as Kisame is from the Akatsuki and Sakura is a Konoha ninja. But then, they find themselves in a situation where they have to work together to survive against a greater threat, like a powerful ancient beast. As they fight side by side, they start to understand each other's motives and pasts, and Sakura begins to see that Kisame is not just a mindless villain.
He might be really good friends with Naruto. Since Naruto is always looking for friends and acceptance, Sakura's twin could be one of the first to see Naruto's potential and befriend him. They could train together and share their dreams of becoming great ninjas.
Sakura's intelligence and her thirst for knowledge could be a great complement to Obito's past experiences and the secrets he holds. Obito might be initially reluctant to share, but Sakura's persistence could draw him out. On the other hand, Obito's once - broken spirit could be healed by Sakura's positive and optimistic outlook. Their personalities could create a dynamic where they learn from each other, with Sakura teaching Obito about modern - day ninja values and Obito sharing his insights from a more chaotic and war - torn past.
Well, they could interact with the Naruto world by getting involved in the village politics. Since they are reborn as someone close to Sakura, they might have an influence on how the Hidden Leaf Village is run. For instance, they could suggest new medical policies based on their modern knowledge. Also, they could befriend other characters like Naruto and Sasuke, and through their interactions, they could introduce new ideas and technologies to the ninja world. This would not only change their relationships but also the overall dynamic of the Naruto world.
She might become more aggressive. Saiyans are known for their fighting spirit and aggression in battle. Since Sakura is a fan, she could start to adopt some of these traits. For example, she may be more willing to take on opponents head - on rather than relying on her more strategic ninja approach all the time.