It could be a power - hungry politician who wants to use the Hulk as a weapon to gain more control during the Civil War. This person might not care about the destruction the Hulk could cause, just as long as they achieve their own goals.
Mr. Sinister could be a great antagonist. He's always interested in mutant genetics and power. He could be the one secretly pulling the strings, making Cable and Deadpool believe they need to fight over the future of mutantkind. He could plant false evidence or use his mind - control abilities on some of the supporting characters to fuel the conflict.
It could be Mysterio. He's known for his illusions and deception. In the context of a civil war, he could use his powers to create false scenarios that make the heroes fight each other even more. He might pretend to be a hero on one side, but secretly be working to make the conflict worse for his own gain.
A new supervillain could emerge. Maybe a scientist who got access to some of the leftover technology from the Civil War battles and uses it to create a powerful weapon. He then targets Spiderman because he represents the superhero community.
It could be a Miraculous holder who has been corrupted by the power. They might start to think that they should be the sole leader and use the civil war as a means to take over. For example, if a holder of a powerful Miraculous like the Bee Miraculous turns bad, they could be a formidable antagonist.
Green Goblin is another option. He might take advantage of the divided superhero community. He could target Spider - Man specifically, knowing that with the other heroes at odds, there's less chance of them coming to his aid. He could also try to use the conflict to his advantage in his criminal activities, like stealing from places that are unguarded because the heroes are busy fighting each other.
The Abomination could be a great main antagonist. He already has a history with the Hulk and his hatred for Hulk could extend to She - Hulk as well. He could be trying to create a new gamma - based weapon to finally defeat the Hulks once and for all.
Loki could be a great main villain. He could be secretly fueling the Civil War for his own gain, like trying to take over Asgard while everyone is distracted. He has the cunning and the motivation to do so.
The Kingpin could be a great main villain. He could see the Civil War as an opportunity to expand his criminal empire. He could be secretly funding both sides in a way that makes the conflict worse, all while Spider - Man is trying to figure out his role in the war.
A padawan who has just come of age and is now thrust into the chaos of the civil war could be a main character. Their inexperience and fresh perspective could add an interesting dynamic.
A group of former war criminals who were pardoned but now want to take over the ninja world. They might have formed a secret organization during their time in prison or exile. They could be using new, dark jutsus that they developed in secret to try and overthrow the current leadership in the villages and establish their own rule.