A plot could involve Peter traveling to the future. He might see a dystopian New York where his loved ones are in danger or his identity has been misused. He then has to figure out how to change the future while also dealing with the advanced technology and new villains of that time. It could be a race against time to fix things before it's too late.
Another plot could be Peter accidentally traveling to different points in time during his experiments. He keeps bouncing around different eras of his own life and the history of New York. In each time period, he has to deal with the local threats as Spider - Man without disrupting the timeline too much. He also gets to see how his actions in one time can have a butterfly effect on other times.
Another idea is that Peter is sick and hallucinating. He starts seeing alternate versions of himself from different universes. These versions are trying to tell him something important about his powers or a future threat. But because he's sick, it's hard for him to distinguish between what's real and what's just a fever - induced dream.
One interesting plot could be Peter Parker using his newfound knowledge from his rebirth to prevent some major disasters that originally happened in the Spider - Man storylines. For example, he might be able to stop the death of a certain important character much earlier.
One interesting plot could be Peter Parker adjusting to his blindness while still trying to protect his neighborhood. He might rely more on his other senses like enhanced hearing to detect danger. For example, he could learn to 'hear' the footsteps of approaching villains from a distance. Another plot could involve his friends and family helping him adapt, and in the process, they discover new abilities within him that were previously overlooked due to his focus on his spider - abilities.
Another plot is one where Mysterio fakes his death and then comes back to seek revenge on Peter Parker in a very elaborate and mind - bending way. The fanfiction plays with the idea of false identities and how far someone will go for revenge. It has Peter constantly on his toes trying to figure out what's real and what's not.
One interesting plot could be Peter using his gamer skills to upgrade his Spidey - sense. For example, he might be able to analyze threats more precisely like in a game where he levels up his detection ability.
The Green Goblin could be a great main antagonist. Imagine if he also got his hands on some time - traveling technology. He could be causing chaos throughout different timelines, trying to establish his own rule in different versions of New York. Peter would have to chase him through time to stop his evil plans.
One common plot is that Peter's friends and family take care of him. For example, Aunt May might fuss over him, making him soup and ensuring he takes his medicine. Another plot could be Peter trying to hide his sickness while still being Spider - Man. He might struggle to keep up with his superhero duties while feeling unwell.
One interesting plot could be Peter Parker getting lost in a strange dimension and Stephen Strange has to use his magic to find and rescue him. This would involve a lot of cool magical battles and Peter using his spider - skills in an otherworldly setting.
One interesting plot could be that Peter Parker discovers a new form of dance that actually helps him improve his Spider - Man reflexes. He starts secretly training in this dance style in an abandoned warehouse. As he gets better at it, he also uses it to outwit his enemies in a really unique way during battles.
One interesting plot could be that while sleepwalking, Peter Parker accidentally uses his Spider - Man abilities. He might swing between buildings unconsciously, causing chaos in the city. People are both amazed and worried as they see Spider - Man acting so strangely.