The Titans or Giants that were banished to Tartarus could be the main antagonists. They might see Percy as a threat or an opportunity to escape and seek revenge on the Olympians.
Some of the more powerful and malevolent monsters native to Tartarus, like the Arai or the Kampe, could also be major antagonists. They would try to stop Percy from achieving his goals, whether it's escaping or finding something important.
The Titans that were banished to Tartarus could be major antagonists. They might see Percy as an intruder and a threat, and try to stop him from escaping or even try to use him for their own purposes. Also, the various monstrous creatures native to Tartarus, like the Empousai or the Arai, could constantly be attacking Percy.
Some of the more powerful and vengeful spirits in Tartarus could be the main antagonists. These spirits could possess demigods or mortals close to Percy to get to him. They might be angry that he escaped their domain and want to drag him back. Additionally, there could be a group of rogue demigods who believe that Percy has been corrupted by Tartarus and they see it as their duty to stop him, even if it means becoming his enemies.
There could also be a group of demigods who are jealous of Percy's power due to his unique parentage. They might form an alliance against him, trying to steal his powers or at least make his life difficult. They could be led by a demigod who has a grudge against Percy or is power - hungry.
His friends like Annabeth or Grover could be the ones to rescue him. They might discover a way into Tartarus and brave all the dangers to get to Percy.
The monsters native to Tartarus could also be antagonists. These could be huge, grotesque creatures that have never seen the outside world. They might attack Percy on sight, seeing him as prey. Some of them could be powerful enough to even give Percy a hard time, especially if his powers are weakened in Tartarus.
The main antagonist could be Nyx. She is a powerful primordial goddess of the night, and Tartarus is her domain in a way. She might see Percy as an intruder and try to stop him from escaping or achieving his goals there.
Perhaps there's a new villain, a powerful sorcerer who has a vendetta against Percy. The sorcerer discovers that Percy is now at high school and decides to target the school. He uses his magic to create illusions and manipulate the minds of the students and faculty, turning them against Percy. The sorcerer might also be after the secrets Percy learned in Tartarus, thinking it can give him more power.
A third plotline could be Percy's search for a powerful artifact or knowledge in Tartarus that could help him in his future battles or save his friends. Along the way, he discovers secrets about the origin of the gods or the true nature of Tartarus itself, which changes his understanding of the world he thought he knew.
In the fanfiction, the environment of Tartarus itself could be considered an antagonist. The extreme heat, the toxic gases, and the ever - present danger of falling into bottomless pits. And on top of that, there could be some sort of demon - like creatures that are specifically created or summoned to hunt down Percy and Zoe and prevent them from achieving their goals.
It's also possible that there could be a new, unknown force in Tartarus that has been awakened by Percy's presence. This new entity could be extremely powerful and oppose Percy at every turn. It might be some sort of ancient, primordial being that has its own motives for not wanting Percy to succeed in whatever his mission in Tartarus is.