Rachel from Glee and Cisco from The Flash would make an interesting pair. Rachel is very ambitious and talented in music, and Cisco is a tech - genius. They could collaborate on creating some sort of musical - tech device. Maybe Rachel's high - pitched singing could be used to power up Cisco's latest invention, or Cisco could create a device that amplifies Rachel's voice to reach across the city, like a musical - based alarm system.
Kara and Rachel would be an interesting pairing. Kara with her superpowers and Rachel with her powerful voice. They could learn from each other, like Kara teaching Rachel some self - defense moves and Rachel helping Kara with her stage presence.
Definitely Barry and Dean. Barry's positive attitude and scientific mind would contrast well with Dean's tough - guy, no - nonsense hunting style. Another interesting pairing could be Iris and Sam. Iris is a strong - willed journalist, and Sam is the more intellectual and empathetic Winchester. And then there's Cisco and Castiel. Cisco's love for creating new tech and Castiel's otherworldly nature would make for some really fun interactions.
Yukari (from Persona 3) and Chie (from Persona 4). Yukari is very outspoken and has a bit of a sarcastic side, while Chie is energetic and a bit of a tomboy. Their different personalities could lead to some really fun and comical interactions, especially when they're facing Shadows together or just hanging out in the school setting.
I think Loki would be really interesting. He's always the trickster in the Avengers world. In a crossover with Glee, he could use his magic to create some wild and wacky musical illusions. He might even try to take over the Glee club and turn it into his own little kingdom of chaos.
Edward and Phoebe would be a fascinating pair. Edward's mind - reading ability and Phoebe's premonition power could lead to some intense and interesting interactions. They could also use their powers together to predict and prevent disasters in the crossover world.
Naruto and Lion - O would be an interesting pairing. Naruto is full of energy and determination, and Lion - O is a noble leader. They could learn from each other's leadership styles. Naruto could show Lion - O how to inspire through his own brand of perseverance, and Lion - O could teach Naruto about the responsibilities of being a true leader. Another interesting pairing would be Sakura and Cheetara. Sakura has her medical ninjutsu skills and combat abilities, while Cheetara is fast and agile. They could train together and exchange fighting techniques.
Naruto and the Penguin would be an interesting pairing. Naruto's naivete and Penguin's deviousness would create a great contrast. Naruto might try to reform Penguin, seeing the good in him, while Penguin would be constantly plotting against Naruto, creating a lot of comical and tense situations.
Willow from Buffy's world and Davina from the Originals could make for an exciting pairing. Willow is a powerful witch, and Davina is also very talented in magic. They could exchange spells and knowledge, and maybe even create new magic together to fight a common enemy.
Ruby and Cayde - 6 would be an interesting pairing. Ruby is young and full of energy, always eager to learn and fight. Cayde - 6 is a witty and experienced Guardian. Their interactions could be really fun, with Cayde - 6 teaching Ruby some of his trick - shooting skills and Ruby showing Cayde - 6 the beauty of her Crescent Rose. Another great pairing would be Weiss and Ikora Rey. Weiss is a highly - trained fighter with a strong sense of discipline, and Ikora Rey is a powerful Warlock with great knowledge. They could share their knowledge of magic - like abilities, Weiss with her Glyphs and Ikora with her Light - based spells. Yang and Zavala could also be an interesting pair. Yang is all about brute strength and a go - getter attitude, while Zavala is a respected leader. Yang could learn about leadership from Zavala while Zavala could admire Yang's tenacity.