A plotline could revolve around Sakura trying to understand Tsunade's past more deeply. Tsunade might be reluctant at first, but as they work together more closely, she starts to open up. This could lead to Sakura learning important life lessons from Tsunade's experiences, like how to deal with loss and keep going. They could also get into a situation where they have to use their combined medical and combat skills to save a group of injured ninjas.
Perhaps a plot where Tsunade decides to pass on her title as Hokage to Sakura in the future. So, she starts to train Sakura not just in medical ninjutsu and combat, but also in leadership skills. Sakura struggles with the new responsibilities and the pressure that comes with it. Tsunade is there to guide her through, and along the way, they strengthen their bond as mentor and mentee.
One possible plotline could be Tsunade teaching Naruto more about medical ninjutsu. Since she is a great medical ninja, she could pass on her knowledge to Naruto, which would add a new dimension to his skills. Another aspect could be her guiding Naruto in leadership, as she is the Hokage. This might help Naruto in his future role as a leader in the village.
Perhaps in the fanfic, Futa is a new character in the Naruto world who has some sort of connection to Tsunade's past. Naruto gets caught in the middle of their relationship. It could involve Futa having some secrets that Tsunade is desperate to know, and Naruto helps in uncovering those secrets while also growing as a ninja himself.
A possible plotline could be a training arc. Tsunade could be training both Naruto and Sakura in a new and advanced form of combat or medical ninjutsu. This would involve a lot of character development as they struggle to master the new skills. For example, Naruto might have trouble with the precision required in a medical - related technique while Sakura helps him out, and Tsunade observes and gives tough love guidance.
Perhaps it could be a story where Marrow is injured during a battle and Sakura, being a medical ninja, has to treat him. Kimimaro, who has his own reasons for being there, observes their interaction. This could lead to a series of events where they all get involved in a mystery that is related to some ancient power. Kimimaro might be initially seen as a threat by Marrow and Sakura, but as they dig deeper, they find out that he is also a victim of certain circumstances.
Maybe Sakura teaches Sasuke about emotional control. Sasuke has always been brooding and angry, and Sakura, with her more empathetic nature, could show him how to manage his emotions better. This could lead to Sasuke becoming a more well - rounded ninja and a better teammate.
One possible plotline could be that Madara kidnaps Sakura to use her as a bargaining chip against Naruto and the Hidden Leaf. Maybe he thinks her medical skills can be useful to heal his own troops or himself. Another could be that Madara has some strange fascination with Sakura's strength and potential, and wants to study her or turn her to his side.
Maybe Sasuke is jealous because Sakura has achieved some great feat in the ninja world and is getting a lot of attention. In the fanfic, this could lead to Sasuke training even harder to prove himself worthy of her. Sakura, on the other hand, might be confused by Sasuke's sudden distance. She could try to reach out to him, but Sasuke's pride and jealousy keep him from being receptive. It could all come to a head during a dangerous encounter with a powerful enemy where they finally communicate their feelings.
One possible plotline could be that Sakura is injured during a difficult battle. Tsunade, as the experienced healer and mentor, tends to her. In the process, they share a moment of intense emotion and end up kissing as a sign of their deep bond. Another could be that they are celebrating a great victory for the village and in the euphoria of the moment, they kiss. Maybe it starts as a friendly peck but then turns into something more meaningful.
Another plotline might be that Tsunade is affected by some kind of dark magic or genjutsu that makes her turn against Naruto. Naruto, realizing it's not really Tsunade's fault, still has to fight her to try and break the spell. He could call upon his friends for help, but in the end, it's his determination and his bond with Tsunade that helps him reach her and break the control.
One possible plotline could be that Naruto leaves with Tsunade on a mission to find a rare herb that is said to have the power to heal any wound. Along the way, they face various enemies who also want the herb for their own malicious purposes. Naruto's skills and Tsunade's wisdom would be put to the test as they battle their way through.