Perhaps Peter forgets his relationships. He doesn't recognize Mary Jane or Aunt May. This could lead to some really emotional moments as they try to jog his memory. And villains might take advantage of his confusion to try and defeat him once and for all.
One idea could be that Peter forgets his identity as Spider - Man. He starts to notice his strange abilities but has no idea where they come from. So he embarks on a journey to figure it out, all while his friends and family are trying to figure out what's wrong with him.
Peter Parker as a scientist might be researching a way to cure a certain disease that is spreading in the city. However, the main villain gets wind of his research and wants to use it for evil purposes. Maybe to create a biological weapon. Peter has to race against time to complete the cure and also protect it from the villain. He could use his spider - powers in creative ways within the lab to fend off the bad guys. For example, using his webs to create barriers around his experiments or swinging around to avoid attacks while still working on the cure.
A possible plot could be that a powerful artifact is stolen and both Marinette and Peter Parker are separately investigating it. They cross paths and initially suspect each other. But as they start to share information, they realize they are on the same side. Marinette's kwami could also interact with Peter in a really fun way, like giving him some extra powers for a short time. This would lead to some comical and action - packed scenes.
One plot idea could be that Shuri and Peter Parker meet during a scientific exchange program between Wakanda and Stark Industries. They start off as rivals, constantly trying to outdo each other in terms of scientific knowledge and gadget - making. But as they face a common threat, like a new villain who is stealing advanced technology from both places, they have to team up. Along the way, they begin to respect and like each other's skills and personalities, eventually becoming friends and perhaps something more.
One idea could be that Peter tries to find a way to coexist with Venom without losing his own mind. He could use Venom's powers for good in a new and unique way, like being able to heal people with Venom's symbiotic abilities. Another plot could be Venom getting separated into multiple parts and Peter has to track them all down before they cause chaos. Maybe one part of Venom attaches to a villain and gives them enhanced powers that Peter has to face.
A great plot might be Peter getting an offer to join a special science program right after graduation, but he's hesitant because it would mean leaving New York and his Spider - Man responsibilities. Meanwhile, at graduation, a super - villain decides to attack the ceremony to get revenge on Spider - Man. Peter has to protect his classmates and teachers without revealing his identity.
One plot idea could be that Peter Parker and Artemis team up to stop a powerful criminal organization that is stealing ancient artifacts and using them for evil purposes. Their combined skills, Peter's super - strength and spider - sense, and Artemis' archery and hunting skills, would make for an exciting adventure.
A really interesting plot could be that Gormora and Peter Parker accidentally swap powers. Peter has to figure out how to control Gormora's powers while she tries to adapt to his spider - abilities. It would be a fun exploration of how they both view and use each other's powers. Also, a plot where Gormora's past enemies from her own world come to Earth, and Peter has to help her defend it, while also dealing with his own superhero duties in New York. This could create some great action - packed and emotional scenes as they bond over protecting the planet.
One plot idea could be that Flash discovers Peter's secret identity as Spider - Man by accident. For example, he might see Peter changing into his suit in a secluded area. Another idea is that they have to team up to solve a mystery in their school, like a series of strange disappearances. Maybe Flash initially refuses to believe Peter's abilities but then witnesses him in action and has a change of heart.
Perhaps the stalker is a new character who has a misguided admiration for Spider - Man. They think that by stalking Peter, they can get closer to the superhero lifestyle. They might leave little gifts or notes for Peter, which at first seem harmless but gradually become more and more intrusive, making Peter feel very uncomfortable and on edge.
Maybe an experiment goes wrong and Peter Parker's spider - sense gets amplified to an extreme level. He has to learn to control it while also dealing with new villains who are attracted to this strange new power. For example, a villain who can manipulate electromagnetic fields that disrupt Peter's amplified spider - sense.