Another plot twist could be that Itachi is under some sort of mind - control or illusion when he abducts Sakura. This could lead to a scenario where Sakura has to find a way to break the control on Itachi and in the process, they form an unexpected alliance. It would add an element of mystery and a chance for character development for both of them.
One possible plot twist could be that Itachi has been mind - controlled to kidnap Sakura. Maybe an enemy of Konoha has a powerful jutsu that forces Itachi to do this against his will. Another twist could be that Itachi kidnaps Sakura as a means to protect her from a greater threat in the shinobi world that no one else is aware of yet. He might know that she has some sort of power or knowledge that makes her a target, and by kidnapping her, he can keep her safe in a hidden location.
A really interesting plot twist could be that Shisui and Itachi find out that Sakura has a connection to an ancient and powerful clan that they didn't know about before. This connection could bring in new elements to the training, like special techniques or a deeper understanding of the ninja world that they have to incorporate into her training.
One possible plot twist could be that Itachi's past actions as a double agent in Akatsuki are revealed in a new light because of the baby. Maybe his enemies try to target the baby to get revenge on him, but Sakura, being a strong kunoichi, defends the baby with all her might. This could lead to a series of battles and alliances being formed in the shinobi world to protect the new life.
A possible plot twist could be that Sakura discovers Itachi's true intentions about the Uchiha Clan massacre much earlier. Since they are the same age, she might be in a better position to understand his motives or even try to prevent it. Another twist could be that Itachi sees Sakura as a potential threat to his plans because of her intelligence and strong will, which could lead to an unexpected conflict between them.
Well, perhaps they are captured by a powerful new organization that has been secretly observing them. This organization could be made up of powerful shinobi from different villages who believe that Naruto and Itachi pose a threat to their new world order. They capture them to try and brainwash them into joining their cause, but Naruto and Itachi resist and find a way to escape together, forging a stronger bond in the process.
One possible plot twist could be that Sakura has been secretly training a new jutsu and uses it to outwit Orochimaru at the last moment. For example, she might have developed a genjutsu that can counter Orochimaru's mind - control techniques. Another twist could be that Naruto and Sasuke arrive just in time, but instead of a straightforward rescue, they find that Sakura has made a deal with Orochimaru in order to gain some powerful knowledge. This could lead to a rift between her and her teammates.
Perhaps in this fanfiction, Itachi has a certain 'weight' of expectations or a mission that somehow involves Sakura. She might be struggling to deal with his decisions or the way he's affecting the situation around her. For example, if Itachi is on a path that goes against Sakura's beliefs, she could be fighting internally on how to react or whether to try and change his course. Another possibility is that Itachi has some form of power or ability that is creating a difficult environment for Sakura to operate in, and she is struggling to adapt or overcome it.
Maybe Itachi, despite his stoic nature, starts to have an unexpected soft spot for Sakura. He could be secretly protecting her during her missions, which might lead to some tense and mysterious moments as Sakura tries to figure out who her mysterious protector is.
One possible plot could be that Sakura discovers Itachi sleeping in an unexpected place, like a hidden grove. She is initially startled but then becomes curious. As she watches him sleep, she might notice his peaceful expression and start to think about how complex he is as a person. She could then decide to stay and protect his resting place until he wakes up, leading to a conversation where they exchange views on life and the ninja world when he wakes.
One possible plot could be that Sakura, eager to improve her skills, seeks out Itachi. Itachi, seeing her determination, decides to train her in the ways of genjutsu. He starts with the basics, teaching her how to detect and break simple genjutsu. Sakura, being a fast learner, quickly grasps the concepts. As the training progresses, they face challenges together, like dealing with rogue ninjas who try to disrupt their training. This not only tests Sakura's newfound skills but also deepens the bond between her and Itachi.