It could be a villain who wants to steal all the cookies in the world. This villain sees Android 18's new - found love for cookies as a threat to his plan, so he tries to stop her from spreading the joy of cookies.
Well, it could be that Android 18, while exploring a strange new world, comes across a magical cookie. When she eats it, she starts to have strange cravings for more cookies and gradually her personality changes to be more obsessed with cookies. She might start going on adventures to find the rarest cookies in the universe.
There could be a group of mean - spirited fairies. They see Sakura as an intruder in their territory, which might be a beautiful garden that Sakura often visits. To drive her away, they use their fairy magic to turn her into a cat, thinking that she will be less of a threat in that form. And they keep thwarting her attempts to turn back into a human throughout the fanfic.
A powerful and jealous digimon who has always been envious of angewomon's status and power could be the main antagonist. They might have found a way to turn her into a keychain to get rid of her.
Perhaps the main antagonist could be a dark magic user who was the one responsible for turning Harry into a girl in the first place. Their goal might be to disrupt Harry's life and his role in the fight against the dark forces. This antagonist could continue to create obstacles for Harry as a girl, like trying to prevent him from getting the help he needs to change back or causing trouble for his friends who are trying to support him.
Maybe the main antagonist is a jealous rival. This rival is envious of her abilities and status, so she uses a forbidden magic to turn her into a card. The rival then tries to take her place in the story, but her friends start to suspect something is wrong and begin to investigate.
A powerful and jealous Digimon could be the antagonist. Maybe a Digimon that has always envied Angewomon's grace and power. This Digimon finds a way to turn her into a doll to get her out of the picture and claim her status in the Digital World.
It could be Orochimaru. He might see Naruto's new form as an interesting experiment or a threat to his plans. He could try to capture Naruto to study her newfound female - related powers or use her in some dark jutsu.
The main antagonist could be the one who turned Percy into a monster in the first place. Maybe it's a vengeful god who feels Percy has wronged them in some way and decides to punish him by turning him into a fearsome beast.
It could be a powerful vampire hunter who believes Naruto, as a new vampire, is a threat to the balance between humans and vampires. This hunter might be from a long line of slayers and is determined to eliminate Naruto before he fully embraces his vampire side.
Perhaps a powerful sorceress. She could be jealous of Robin's connection to Batman and the other heroes, so she uses her magic to turn Robin into a girl as a way to humiliate and weaken him. The sorceress could then try to use Robin's new form to her advantage, like trying to make Robin turn against the heroes or something.