Perhaps there is a dark force that is awakened by the oc's reincarnation. This force might have been dormant for a long time, and the oc's new life energy or something about their reincarnation stirs it. It could be a force that wants to destroy the balance of the pjs world, and the oc is the only one who can stop it because of their unique perspective from their past life.
One idea could be that the oc retains some memories of their past life. So they use their knowledge to change things in the pjs world. For example, they might know of a coming danger and work to prevent it.
It could be an old enemy from Percy's past life who has also found a way to be reincarnated. This enemy might hold a grudge against Percy for something that happened in their previous encounter and is now seeking revenge in this new life.
It could be a new character created specifically for the fanfiction. Maybe a powerful pirate who has a vendetta against the Straw Hat crew because of the oc's presence. Since the oc is reborn into this world, they might bring some sort of change that angers this new antagonist.
Maybe there is a new character created specifically for this fanfiction as the main antagonist. This new character could have a connection to the oc's past life or the reason for their rebirth. They might be trying to prevent the oc from fulfilling a certain destiny or unlocking their full potential.
It could be another powerful ninja who sees the student as a threat to their own power or plans. Maybe someone who doesn't want Madara to pass on his knowledge to an outsider or a young upstart.
An ancient and powerful entity that has awakened from a long slumber. It could be some sort of dark psionic being that wants to consume all life in the galaxy, starting with the Protoss and the OC's army.
Another possibility could be an original antagonist created specifically for the fanfiction. For example, a powerful sorcerer from a hidden dimension who sees the OC's rebirth as a disruption to the natural order of the MCU universe. This sorcerer could try to eliminate the OC and use their power for their own dark purposes. They might be able to manipulate magic in ways that even Doctor Strange hasn't seen before, making them a formidable foe.
Perhaps another reborn character could be the main antagonist. Say, an evil sorcerer from the past who was also reborn in the Inuyasha world at the same time as the OC. This sorcerer has his own agenda of ruling the world and sees the OC as a threat to his plans, especially if the OC is getting in the way of his attempts to gather the Shikon Jewel fragments.
Maybe it's a new pirate crew led by a character with a Devil Fruit power that can nullify the OC's Gamer abilities. This pirate captain is extremely ambitious and wants to rule the New World. He views the OC as an obstacle in his path because the OC has the potential to disrupt his plans, especially if they can use their Gamer skills to form alliances against him.
It could be a dark wizard who has a vendetta against Erza and sees her son as a way to get revenge. This antagonist might try to corrupt the OC son or use him as a pawn in his evil plans.