Well, Naruto and Symmetra could have a really cool interaction. Symmetra is all about order and structure, and Naruto, while he has his own sense of justice, comes from a world that is very different in terms of architecture and technology. They could clash initially over their different views, but then find common ground. And of course, Naruto and Soldier: 76 would be great. Soldier: 76 is a veteran with a strict code, and Naruto's energetic and often unorthodox ways could either annoy or inspire him. They could work together to lead the team in a fight against a powerful enemy.
One possible plot could be that Naruto, in his Six Paths form, somehow gets transported to the Overwatch universe. He might initially be confused by the high - tech environment. He could then meet some of the Overwatch heroes, like Tracer. Maybe they start off as foes, with Naruto's power being seen as a threat. But as they learn more about each other, they team up to face a common enemy that is threatening both the world of Overwatch and Naruto's own world.
Definitely Naruto and Twilight Sparkle. Twilight is all about knowledge and magic, and Naruto has his own unique ninja powers. They could have really deep conversations about how their powers work and share knowledge. Maybe Twilight could try to study Naruto's chakra system using her magic, and Naruto could be amazed at how Twilight's magic can do things like levitate objects and create spells.
Definitely Naruto and the Little Sisters. Naruto has a soft spot for those in need, and the Little Sisters are in a very vulnerable position. He would probably be very protective of them, and the contrast between his energetic and positive personality and their rather timid and strange existence would be fascinating.
The interaction between Naruto and Rukia could be great. Naruto's exuberance and positive attitude could contrast with Rukia's more serious and stoic nature. They could bond over their loyalty to their friends. Maybe Naruto could make Rukia laugh with his silly antics, and Rukia could teach Naruto some of the more refined aspects of combat from the Soul Society.
Reinhardt and Yang would be quite a pair. Reinhardt is the fearless crusader with his rocket - powered hammer and shield, while Yang is a brawler with her gauntlets. They could have some epic battles side by side, and Yang could learn about honor and chivalry from Reinhardt, while Reinhardt could be impressed by Yang's tenacity and determination in the face of danger.
Naruto and Kenichi himself would be really interesting. Kenichi could be in awe of Naruto's power and his never - give - up attitude. Naruto could see Kenichi's determination to improve in martial arts and be reminded of his own journey to become a great ninja. They could train together, with Naruto teaching Kenichi some basic ninja moves like how to throw shuriken accurately, and Kenichi teaching Naruto some martial arts stances.
Sasuke and Zoro could have some cool interactions. They are both very strong and somewhat brooding characters. Zoro might be interested in Sasuke's Sharingan and the power it holds, while Sasuke could be intrigued by Zoro's three - sword style.
Definitely Harry and Gaster. Harry is used to the magic in his world, while Gaster has his own set of abilities. Their meeting would be full of confusion, curiosity, and perhaps a bit of wariness. Another interesting interaction could be between Hermione and Gaster. Hermione would be eager to learn about Gaster's knowledge and would probably bombard him with questions.
Naruto and Moka would be really interesting. Naruto's brashness and Moka's dual - nature (the sweet and the vampire side) could lead to some great interactions. He might be constantly trying to get her to show her true vampire self, while she could be both intrigued and a bit annoyed by his antics.
Definitely Naruto and Issei. Issei is all about perverted thoughts and power - seeking, while Naruto is more about friendship and protecting his comrades. Their interactions would be full of contrasts and they could learn a lot from each other.