A rogue ninja from a formerly warring village could be the main antagonist. This ninja might hold a grudge against the new peace and wants to disrupt it. He could be powerful and have his own group of followers who are also discontent with the current situation.
A new supervillain could emerge. Maybe a scientist who got access to some of the leftover technology from the Civil War battles and uses it to create a powerful weapon. He then targets Spiderman because he represents the superhero community.
It could be a power - hungry shinobi from another village. This shinobi sees Naruto's exile as an opportunity to gain more power and influence in the ninja world. He might try to hunt Naruto down to prove his own strength or to steal Naruto's secrets.
Perhaps a secret organization within the Hidden Leaf that wants to take over the village. They use Naruto as a scapegoat, getting him banished so they can carry out their evil plans without interference from Naruto. They would be the main antagonists as they are the ones behind the false accusations and the push for his banishment.
Perhaps a new, unknown force. With Naruto gone, a previously hidden group with a vendetta against the ninja villages could emerge. They might blame the villages for the destruction caused during the war and see Naruto's death as the perfect time to strike, when the villages are still recovering and vulnerable.
Maybe it's an old enemy who survived the war and has grown stronger. They hold a grudge against Natsu and his friends and are now seeking revenge. For example, if there was an enemy that was thought to be defeated before the war but managed to survive and is now back with a vengeance.
There could be a mysterious figure from Naruino's past during the war. This person has a grudge against Naruino and resurfaces in the post - war period to seek revenge, creating all sorts of problems for Naruino.
It could be some of the traditionalist elders in the Hidden Leaf. They might see Naruto as a threat even after the war, fearing his growing power and influence, and thus engineer his banishment. So they could act as antagonists as Naruto tries to find his place outside the village.
It could be a rogue demigod who was on the losing side of the Giant War and is now seeking revenge. This demigod might have found some dark power or be allied with some minor but dangerous mythical creatures.
Another possibility is a vengeful former Death Eater's apprentice. This person blames Harry for the downfall of their master and the loss of the Death Eater regime. Seeing Harry as a weakened target because of his blindness, they plot to exact revenge on him. They might use dark magic to create illusions and traps specifically designed to disorient Harry, taking advantage of his lack of sight.
It could be a rogue ninja who was once part of a minor group during the war but has now risen to power. Maybe they felt overlooked or mistreated during the war and now seek revenge on the major villages.