Sakura would definitely be a main character. Her relationship with Naruto has always been complex in the original Naruto story. And from Supergirl's side, Cat Grant could be involved. She is a powerful and influential figure. Her presence in the story could add a touch of glamour and her interactions with Naruto and the other characters in the harem could lead to some really engaging storylines.
Hinata could be one of the main characters. Since she has deep feelings for Naruto in the Naruto universe, she might follow him into Supergirl's world. Also, Kara's friend Lena Luthor could be involved. She is a complex character and her interaction with Naruto could add an interesting dynamic to the story.
Ino from Naruto's world would be a likely candidate. She is strong - willed and confident. In Supergirl's world, Alex Danvers could play an important role. She is a tough and intelligent character, and her reaction to Naruto and the developing harem situation could be quite interesting. Maybe she is initially suspicious of Naruto but then grows to respect him.
One possible plot could be that Naruto, through some sort of multiverse portal, ends up in Supergirl's world. He brings his unique ninja skills and charisma. The harem aspect could involve several female characters from both Naruto's and Supergirl's universes being attracted to him. For example, Sakura from Naruto's world might follow him through the portal, and in Supergirl's world, characters like Lois Lane could also be drawn to his mysterious abilities and kind heart.
Madara Uchiha could be a great antagonist. His powerful Sharingan abilities and his grand plans for the Naruto world would put him at odds with Supergirl. He might see her as a threat to his control and try to manipulate or defeat her. Another option could be Kaguya Otsutsuki. Her god - like powers and desire to reshape the world would clash with Supergirl's values and her attempts to protect the people of the Naruto universe.
It could be an evil ninja from Naruto's world who somehow gains Kryptonian - like powers. He becomes power - hungry and decides to take over both the Naruto world and Supergirl's world. His knowledge of ninja techniques combined with super strength and other abilities would make him a formidable foe.
The main villain could be Darkseid. Imagine if he somehow finds a way to enter the Naruto universe. He would be a formidable foe for both Naruto and Supergirl. His omega beams and immense strength would be a huge challenge for them to overcome.
Naruto could save Supergirl by using his speed. His ninja training has made him extremely fast, and he could use this speed to quickly move Supergirl out of harm's way when she is in danger, like when she is facing a powerful energy blast from an enemy.
Sakura could be an interesting addition. She might be jealous at first when she sees Naruto in a harem situation with Tayuya but then realizes she also has feelings for Naruto in a different way. Another character could be Ino. She could be friends with Tayuya and get drawn into the harem dynamic, adding more complexity to the relationships.
Sakura could be a potential character. She has a long - standing relationship with Naruto, and in this harem scenario, she might be jealous of Naruko at first but then come to accept the situation. Hinata could also be part of it. Given her love for Naruto, she would be an interesting addition to the harem, adding a shy and gentle dynamic.
Jimmy Olsen could also be a great character to include. He is Superman's friend and colleague at the Daily Planet. His loyalty and his ability to get into some sticky situations can add a touch of humor and also some interesting sub - plots to the Supergirl and Superman fanfiction.
One possible plot could be that Naruto, through some interdimensional rift, ends up in the Young Justice universe where he meets Supergirl. They could start off as strangers, but quickly realize they have a lot in common. For example, both have superpowers and a strong sense of justice. Naruto's ninja skills and Supergirl's Kryptonian powers could combine in interesting ways during battles against common enemies. They might also have to overcome cultural differences, as Naruto is from a feudal - like ninja world and Supergirl from a more advanced, alien - influenced society in the Young Justice world.
Well, it depends on the fanfiction community. Some fans really love the idea of crossovers and romance between such diverse characters. They enjoy imagining Naruto's determination and Supergirl's strength coming together in a relationship. However, others might be more purist about the individual franchises and not be as into it.