There are fanfics like that. Sasuke might leave Sakura for Karin because of Karin's loyalty. Karin has shown unwavering loyalty to Sasuke throughout the series. She was willing to risk her life for him on multiple occasions. In contrast, Sasuke might think that Sakura's love is more of a childhood crush that she hasn't fully grown out of, and he may be drawn to Karin's more mature and selfless loyalty.
One common theme is the exploration of unrequited love. Sakura's love for Sasuke is well - known, and when he leaves her for Karin, it delves into the pain of unrequited love from Sakura's perspective. Another theme is the idea of choosing based on power and usefulness. As Karin has certain powers that can be of help to Sasuke, it shows a theme of practicality in relationships.
One possible reason could be Sasuke's pursuit of power. In many fanfictions, his thirst for greater strength might lead him to leave Sakura behind as he embarks on a solo journey to train in more dangerous and secluded places. He may feel that his goals are too dangerous for her to be involved with.
One possible reason could be a difference in their goals. Sasuke has always been on a journey of revenge and self - discovery. If in the fanfic, Naruto's path starts to conflict with Sasuke's in a way that Sasuke can't tolerate, he might leave. For example, if Naruto decides to fully side with the village elders whom Sasuke distrusts, Sasuke could see this as a betrayal of their friendship and leave. Another reason could be an external threat that forces Sasuke to leave to protect Naruto. Maybe there's a powerful enemy that specifically targets Sasuke and he doesn't want Naruto to get caught in the crossfire, so he leaves without explanation to keep Naruto safe.
One possible reason could be that Karin has unique abilities that are more useful to Sasuke in his goals. For example, her sensing abilities might be crucial in his missions. Also, Karin has a deep loyalty towards Sasuke which he might value more than Sakura's feelings at that time.
Sakura might be heartbroken. She's been in love with Sasuke for so long. She could initially go into denial, thinking it's just a temporary thing. Then she might get angry and vow to prove herself to Sasuke, perhaps by becoming an even stronger ninja.
Well, it could be a story about their complex relationships. Maybe it shows how they interact in a post - war Naruto world. Sasuke might be in the middle of Sakura's love and Karin's lingering feelings for him.
One possible reason in this fanfiction scenario could be that Sasuke feels a stronger connection to Karin on a spiritual or power - related level. Karin has unique abilities that might attract Sasuke more than Sakura's medical ninjutsu. Maybe he sees in Karin a kindred spirit in terms of their past traumas and the way they've had to fight to survive. Also, Karin has always been very devoted to Sasuke, and he might be drawn to that unwavering loyalty.
One reason could be to create drama. The idea of a relationship being broken by cheating is full of emotional turmoil which can make for an interesting read. Another reason might be some writers' preference for the Sasuke - Karin dynamic. They might see potential in their relationship that wasn't explored in the original series.
In this fanfic, they could be suffering from different levels of hangovers. Naruto's hangover might be more physical, with a pounding headache and nausea. Sakura's could be more mental, as she's worried about how she behaved while drunk. Sasuke might be in denial about his hangover at first, but then it hits him hard. Karin could be using her knowledge of herbs to try and make a remedy for them all. There could also be some flashbacks to the night before, showing snippets of their drunken conversations and actions. These flashbacks could reveal some hidden feelings or secrets among the characters, adding more depth to the story.
Perhaps Sasuke starts to notice Ino's unique skills and how they complement his own. Ino has her mind - related jutsus which could be useful in certain missions or battles. This practical aspect, combined with a growing personal bond, might lead him to leave Sakura for Ino.