Who could be the main antagonists in a 'Naruto turns evil' fanfic?

The villagers themselves could be the main antagonists. Since Naruto has been neglected, their continued mistrust and hostility towards him could drive his 'evil' turn. They represent the status quo that has failed Naruto, and he might see them as the source of his problems.

The main antagonists could be the original Naruto's friends and allies. Since this is an evil Naruto, people like Sasuke, Sakura, and Kakashi would likely oppose him and try to stop him from whatever evil plans he has in the past.

The Hidden Leaf Village itself could become the main antagonist. Since Naruto turns evil, the village that once nurtured him would now be against him. The village elders and some of the ninja who oppose Naruto's new evil ways would be in conflict with him. For example, Kakashi might be forced to fight against Naruto to protect the village.

It could be Yuno. Normally they are friends, but if Asta turns evil, Yuno might be the one to oppose him. Yuno has his own strong magic and a sense of justice that would make him a natural adversary.

A jealous classmate could be a main antagonist. This person might be envious of Naruto's popularity and his ability to make friends easily. They could try to spread rumors or sabotage Naruto's projects.

The Akatsuki could still be a major antagonist. Even if Naruto is emperor, they might oppose his rule as it goes against their own goals of chaos and obtaining the tailed beasts.

One possible antagonist could be a jealous noble from Naruto's own kingdom who feels that Naruto doesn't deserve the prince title. This person might try to undermine Naruto at every turn, spreading false rumors about him or trying to sabotage his diplomatic efforts.

Another possible antagonist could be a fellow inmate who has a personal vendetta against Naruto. Maybe this inmate was once on the wrong side of Naruto's actions outside the prison and now sees this as an opportunity for revenge. He could try to undermine Naruto at every turn, from spreading false rumors about him to physically attacking him when the guards aren't looking.

Another option could be Orochimaru. He has his own motives and is always looking for power. He could be the head of a powerful gang in the criminal underworld of the Naruto world. He would constantly be trying to capture Naruto or his friends to use them for his experiments or to gain more power over the ninja world.

The Akatsuki could still be the main antagonists. They might be interested in Naruto's tails for their own dark purposes, like using their power to create a super - weapon or gain control over the ninja world. Another option could be a secret group of rogue ninjas who have a vendetta against the Uzumaki clan and see Naruto's tails as a symbol of their power that they want to destroy.