A group of dark wizards and witches who are against Voldemort's ideology but are even more extreme in their use of dark magic could be the main antagonists. They might target Harry because of his connection to Dumbledore and Bellatrix because of her former association with Voldemort. These antagonists could be operating in the shadows, secretly influencing events at Hogwarts and in the wizarding world. Harry and Bellatrix would need to uncover their plans and stop them before it's too late.
Maybe a powerful dark wizard from another country who comes to Hogwarts in search of powerful magical artifacts. He or she views Harry as a key to finding them and Bellatrix as an obstacle in their path. This new antagonist could have unique and terrifying magical abilities that neither Harry nor Bellatrix have encountered before. They would have to put aside their differences and work together to defeat this new threat. This would create an interesting dynamic in the fanfic as they learn more about each other while facing this common enemy.
It could be a rogue Death Eater who wants to take over Voldemort's position and sees Harry and Bellatrix's new - found alliance as a threat. For example, a Death Eater who was always jealous of Bellatrix's closeness to Voldemort.
Perhaps a new dark wizard or witch who sees Harry as a threat. Since Harry has the power of Voldemort version 2, this new antagonist might fear that Harry will stop their plans for world domination. They could be someone who was in the shadows during Voldemort's time and now wants to take advantage of the chaos that Harry's transformation brings. They would try to use Harry's new identity against him and turn the wizarding world against him even more.
It could be a power - hungry Death Eater who didn't like how Voldemort was running things and decides to take over after his defeat. This character might be even more cruel and calculating than Voldemort, using dark magic in new and terrifying ways.
It could be Draco Malfoy. He might be jealous of Harry getting the teaching position and try to undermine him at every turn. Malfoy could spread rumors about Harry not being qualified or try to disrupt his classes in some devious ways.
It could be an ancient dark magic artifact. The artifact has a hold on Bellatrix, and in a way, it's the 'enemy' that Harry has to defeat to save her. The artifact might be trying to use Bellatrix to carry out some dark plan, like opening a portal to a world full of dark creatures. Harry has to figure out how to break the connection between Bellatrix and the artifact while also fending off the artifact's attacks.
A group of rogue Death Eaters could be the main antagonists. They think that Voldemort has gone soft by teaming up with Harry. So they break away and form their own more extreme and violent group. They start attacking both the wizarding world and anyone associated with Harry and Voldemort's new alliance. Harry and Voldemort must then fight against their former allies who have become a greater threat than ever.
It could be a dark fairy who is jealous of the Fairy King's alliance with the wizarding world. This dark fairy wants to destroy the connection and take over both the fairy realm and the wizarding world.
It could be a rogue Death Eater who decides to carry on Voldemort's legacy in a more extreme way. This Death Eater might have some new and terrifying dark magic up their sleeve.
The main antagonist could be a powerful necromancer who combines the dark arts of Skyrim with some elements of Voldemort - like magic. He could be raising an army of the undead and causing chaos across Skyrim, which Harry has to stop.
It could be a new dark wizard who has a vendetta against Harry. This wizard might use a spell to stop Harry from eating, thinking it will weaken him before a final showdown. He could be someone who was once a follower of Voldemort and now wants to take his place and prove himself by getting rid of Harry.
Maybe an ancient evil spirit that was once bound but is now trying to break free by using the summoner as a conduit. This spirit could be manipulating events from the shadows, causing chaos in the wizarding world to draw the summoner out.