It could be a dark wizard that was previously unknown. Maybe this wizard has a grudge against Harry's family for some long - forgotten reason and is using a very subtle and complex plan to harm Harry. And Fred discovers this wizard's plot when he goes back in time.
Well, perhaps when Fred goes back, he discovers that the danger to Harry is much more complex than he initially thought. There could be a traitor among the people he thought were allies in the past. Also, Fred himself might get stuck in the past and has to find a way to get back while still ensuring Harry's safety. Maybe the time - traveling magic is being manipulated by a hidden enemy, and Fred has to figure out who and how to stop it to save Harry.
She could accidentally change other things in the past. For example, her presence might disrupt some other events that were supposed to happen. Maybe she prevents another character from getting a crucial piece of information, which then has a ripple effect on the future.
There might be a group of people who believe that Sev is dangerous because of his potential power. So they are trying to eliminate him. Lilly has to convince them otherwise or stop them from harming Sev.
One popular fanfiction with this plot is 'Time's Redemption'. In it, Hermione uses a powerful time - turning device to go back. She faces many challenges in the past, like avoiding detection by other characters while trying to figure out how to prevent Fred's death. It's a great read for those who love emotional and action - packed stories.
Another possibility is that an evil wizard from the past, who was previously defeated, gets resurrected or empowered by Harry's time - traveling interference. This wizard could then become the main antagonist, using Harry's actions to their advantage and wreaking havoc on the wizarding world.
The main antagonist could be the Devil himself. He might see Harry as an intruder in his domain and try to keep him there forever. He could set up all kinds of traps and challenges for Harry to overcome.
It could be a time - traveling version of Orochimaru. He might have his own plans for the past and Sasuke's interference could put them at risk. So, he tries to stop Sasuke from changing the past in a way that would undermine his future goals.
It could be Danzo. In the original story, Danzo was a major factor in the Uchiha massacre. If Itachi goes back in time, Danzo would likely still be plotting against the Uchiha. His thirst for power and his extreme methods would put him at odds with Itachi's new attempts to save the clan.
It could be Zeref. If Natsu goes back in time, Zeref might have different plans or be in a more powerful position at that time. He could be the main obstacle for Natsu to overcome, especially if Natsu is trying to change things related to the dark magic that Zeref wields.
It could be a time - traveling version of one of his existing villains. For example, Zoom could have found a way to travel back in time and is trying to change history to make his own future more powerful. Another option is that a new character, a time - keeper type of villain, emerges. This villain's goal is to stop Barry from messing with the timeline and will do anything to preserve the original course of history, even if it means harming Barry.