Well, initially, there would be chaos in the village. People would start to spread rumors about why Naruto left. His closest friends like Sakura and Kakashi would be devastated. They would try to figure out where he went and why. The Hokage at the time would have to make a decision. They could either try to convince Naruto to come back through peaceful means or prepare for the worst - case scenario if Naruto turned against the village. The village as a whole would have to face the fact that one of their most prominent members left, and it would have an impact on their reputation among other villages as well.
The ninja elders in Konoha could see it as a potential threat. They might worry that Fem Naruto leaving could expose Konoha's secrets or that she could be turned against the village by enemies. So, they would start to take measures to protect Konoha's interests. They could send out spies to keep an eye on her or try to find a way to bring her back. On the other hand, the younger generation of ninjas might be inspired by her courage to break free and seek their own paths outside of the village.
Some might be in shock. Naruto, regardless of being male or female in this fanfiction, has been a significant part of the village. People who have come to know her would be surprised that she would leave. They might start to question if there was something they could have done to prevent it.
Hinata would be heartbroken at first. Naruto is someone she deeply cares about. But she's also a strong - willed ninja. So she might start by trying to understand why Naruto left. She could look for clues in the village or talk to Naruto's friends to figure out his possible destination.
He could feel a sense of guilt. Sasuke might think that his actions or their relationship issues pushed Naruto to leave. He may then set out to find Naruto, not only to bring him back but also to resolve their long - standing issues. For example, if there were unspoken words or unresolved fights between them, Sasuke would see this as an opportunity to set things right.
It could lead to political unrest in Konoha. There might be those who blame the village leadership for Naruto's departure. This could lead to power struggles as different factions try to take control and change the way the village is run. Some might demand more transparency and better treatment of their shinobi to prevent such a thing from happening again.
It could create a sense of unease and fear. Naruto is a very powerful ninja, and if he turns dark and leaves, the villagers would be worried about him coming back as an enemy. It might also lead to a decrease in morale among the ninjas who once considered Naruto a friend or ally.
The villagers would likely be shocked. Naruto is a hero to many in Konoha, and Tsunade is the Hokage. Their sudden departure would cause a great deal of confusion and concern. Some might think that Konoha is in danger if two such important figures have left.
Some in the village would be sad to see them go. Naruto is a hero to many, and Hinata is also well - liked. People like Iruka would miss Naruto a great deal. But others might understand their need for a new life away from the village and support their decision.
Shikamaru and the others from the Rookie 9 would be shocked. They have always counted on Naruto to be there in Konoha. They would probably feel a sense of loss and also a bit of guilt, wondering if they could have done something to prevent Naruto from getting so tired of the village. They might try to find ways to get him back, while also respecting his decision if he is determined to leave.
Sasuke might be more understanding. Given his own experiences of leaving Konoha, he could respect Naruto's decision. However, he might also secretly plan to keep an eye on Naruto from afar to make sure he is safe.