One possible plot could be that Orochimaru's daughter is initially raised with his dark teachings. But then she meets Naruto. Naruto, with his positive attitude and belief in people, starts to make her question her father's ways. She could then struggle between her loyalty to her father and the new path that Naruto represents.
Well, it could be that Orochimaru's daughter is sent on a mission to spy on Naruto. But as she gets to know him better, she realizes that he is not the enemy her father made him out to be. This causes her to have an internal conflict. She may start to secretly help Naruto and his friends, all while trying to keep her father from finding out.
The plot might involve the daughter having some unique abilities inherited from Orochimaru. Naruto, being curious and always looking to help people, tries to understand her. Eventually, they might team up to fight against a common enemy. Maybe an old enemy of Orochimaru who wants to use his daughter for some evil purpose.
It could also be a story of redemption. Orochimaru's daughter might be on a quest to make up for her father's wrongdoings. She looks up to Sakura as a role model, someone who has overcome many challenges and has a strong moral compass. Sakura initially is hesitant to trust her, but as the daughter proves her good intentions time and again, Sakura decides to help her in her journey of redemption. Together, they face various enemies who are still holding grudges against Orochimaru and his actions.
In a fanfiction like this, the plot might involve Orochimaru having some hidden motives in becoming Naruto's 'mate'. Maybe he wants to use Naruto's connection to the Nine - Tails to gain more power for himself. But as time passes, Naruto's positive influence starts to change Orochimaru in ways he didn't expect. Naruto, on the other hand, might see Orochimaru as a project, someone he can reform, and this idea of reforming him could be the basis of their relationship in the fanfiction.
In a fanfiction where Naruto becomes an Orochimaru fan, perhaps Orochimaru has a change of heart and starts to use his knowledge for the good of the village. Naruto witnesses this new side of Orochimaru and is inspired. He begins to study Orochimaru's techniques more closely, believing that he can also use them for good. However, others in the village are skeptical and Naruto has to fight to prove that Orochimaru can be a positive influence.
One possible plot could be that Fem Orochimaru, for some reason like a powerful jutsu backfiring on her, is forced to become Naruto's slave. Naruto, being the kind - hearted person he is, might initially be uncomfortable with the situation but gradually tries to understand Orochimaru's past and motives. He could use this opportunity to reform her and make her use her skills for good. For example, Orochimaru's knowledge of forbidden jutsus could be used to help the village in some way.
One possible plot could be that the daughter has to struggle with her dual nature. Since Naruto is human (sort of, with his Uzumaki heritage) and Kyuubi is a powerful tailed beast. She might be shunned by some in the ninja world who fear her power. But at the same time, she could also be a bridge between humans and the tailed beasts, trying to bring peace and understanding. For example, she could use her unique abilities to stop a new threat that targets both humans and tailed beasts.
Well, one possibility could be that she inherits Naruto's determination and Kurenai's intelligence. Maybe she's a prodigy in ninjutsu, and the plot could revolve around her trying to make a name for herself in the ninja world. She might face challenges like discrimination because of her famous parents, but overcomes them with her own skills and the friends she makes along the way.
One possible plot could be that Orochimaru, being his devious self, discovers the existence of the Teen Titans' world. He sees Raven's power and wants to use it for his own gain. Naruto, who somehow ends up in this world too, teams up with the Teen Titans. Naruto's positive attitude and his own set of skills would contrast with Orochimaru's evil plans. He and Raven might initially clash due to their different natures, but as they face Orochimaru together, they start to understand each other and combine their powers to defeat Orochimaru.
It could be that the bite was part of a larger plan by Orochimaru to create a new body for himself. Orochimaru is always seeking new vessels. He might think that Naruto, with his strong chakra and willpower, would be the perfect host. So, Naruto has to fight against Orochimaru's influence from within his own body, while also trying to figure out how to stop Orochimaru's overall plan.
One possible plot twist could be that Orochimaru turns Naruto into a girl as part of a grand experiment. But Naruto, now a girl, still has his (or rather her) strong will and uses this new form to infiltrate an all - female group that Orochimaru wants to target. This way, Naruto can gather intelligence and thwart Orochimaru's plans from the inside.
In this type of fanfiction, it might also be that Naruto joins Orochimaru to spy on him. The Hidden Leaf Village realizes they need to know Orochimaru's plans from the inside. Naruto, being the brave and somewhat reckless one, volunteers for the mission. He endures Orochimaru's experiments and teachings while secretly sending information back to the village. Eventually, when the time is right, he betrays Orochimaru and uses the knowledge he gained against him.