Gaara from Suna might be involved too. Since he has his own experiences with Naruto and also has a connection to the shinobi world. He could be there to either help Naruto or mediate between Naruto and Iwa, depending on how the fanfic is written.
Sasuke could be involved. He and Naruto often have intertwined stories. Sasuke might either be an ally in Naruto's destruction of Iwa, or he could be there for his own reasons, like seeking power or revenge.
There might be characters from Iwa who oppose Naruto. For example, the Tsuchikage of Iwa would surely be involved as the leader of the village Naruto is attacking.
Sasuke would likely be involved. He has his own issues with Konoha and might side with Naruto, either out of friendship or his own vendetta against the village. Also, the elders of Konoha like Danzo could be important characters as they might be the ones behind Naruto's banishment.
Tsunade for sure. As the Hokage and also a medical expert, she would be furious about Naruto escaping the hospital. She might send some ninjas to bring him back.
One possible reason could be a threat to Konoha. If Iwa planned an attack on Konoha, Naruto, as a defender of his village, might take the fight to them and end up destroying parts of Iwa in the process.
Sasuke could be involved. Since they have a complex relationship, Sasuke might either be a rival during Naruto's training, pushing him to be better, or he could end up joining Naruto in some training sessions to become stronger together.
Sasuke is an obvious choice. He has a connection to Naruto that goes beyond just friendship or rivalry. He might be the one who first discovers Naruto's predicament and sets out to find a solution. Sakura is essential too. Her skills as a medical ninja are crucial. She could be the one who patches Naruto up every time he gets injured in his fight against whatever is threatening his life. Also, characters like Jiraiya might make an appearance. Even though he's dead in the original story, in this fanfiction, he could come back as a spirit guide to help Naruto find a way to 'refuse to die', giving him advice based on his own knowledge and experiences.
Sasuke is likely to be involved. He and Naruto have a complex relationship and Sasuke has become an ally. He could offer his strength in combat to protect the rebuilding efforts. Also, Sakura. She's a skilled ninja with medical abilities that could be useful if there are any injuries during the process.
Sasuke would most likely be involved. Since he has a strong bond with Naruto, he would sense something is wrong and try to free Naruto from Kaguya's control. Sakura might also be part of it as she cares about Naruto and would be determined to save him. Kakashi could play a role too, using his wisdom and experience to figure out a way to break Kaguya's hold on Naruto.
Obviously, Naruto is the central character. But other characters like Sasuke could also be involved. Sasuke might be torn between his loyalty to Konoha and his friendship with Naruto. He could either try to bring Naruto back or join him in his exile.
Sasuke could be involved. Since he has a complex relationship with Naruto, if Naruto becomes 'Red X', Sasuke might be either an ally or an antagonist depending on the nature of 'Red X'. Another character could be Kakashi. As Naruto's mentor, he would surely notice the change and try to guide Naruto through it.