Iruka could be a surprising character to abandon Naruto in some fanfictions. Maybe he gets influenced by some outside force or a misunderstanding that makes him think Naruto is no longer the Naruto he knew. And then there are the other genin in Naruto's class. They might abandon him out of jealousy if Naruto starts showing extraordinary powers too quickly. Or they could be pressured by their families who don't want them associated with Naruto.
Sasuke could be a likely character in some fanfiction. Maybe in an alternate universe where their rivalry takes a darker turn, Sasuke might frame Naruto to gain an advantage or to prove his own superiority. It would add a whole new dimension to their relationship.
Obviously Naruto himself is the main character involved. But his friends like Sasuke, Sakura, and Kakashi are also likely to be involved. Sasuke might be affected by Naruto's wishes, for example, if Naruto wishes for Sasuke to fully return to the Hidden Leaf Village and be at peace. Sakura could also be involved, perhaps in helping Naruto make his wishes come true in a medical or support way. And Kakashi, as Naruto's former teacher, would surely play a role in guiding Naruto in how to use his wishes wisely.
Definitely Naruto is the central figure. In the harem, Hinata is a very likely character since she has always been in love with Naruto. Sakura might also be there as she has been one of Naruto's closest friends. Tenten could be another addition. She has interacted with Naruto in the series and could potentially be part of the harem in this fanfiction. Also, Temari, who has had some interesting encounters with Naruto, might be a character in the harem as well.
Sasuke could be one. He's highly intelligent and has his own network of contacts. He might introduce Naruto to some high - paying jobs or business opportunities. Another one is Tsunade. As the Hokage, she has access to a lot of resources and information. She could give Naruto some inside tips on how to make money, like which trade routes are the most profitable or where to find rare and valuable items.
Iron Man is another candidate. Tony Stark's technology and Naruto's ninja techniques could be a great contrast. They could learn from each other. Stark might be interested in Naruto's chakra - based powers and try to replicate them in some way, while Naruto could be amazed by Stark's high - tech gadgets.
Naruto, Sasuke, and Sakura are the most obvious choices. They are the main characters and their interactions are always interesting. Naruto would bring his energetic and fun - loving nature, Sasuke his brooding intensity, and Sakura her intelligence and strong - willed personality.
Naruto himself could be in jail fanfiction. Maybe he was framed for a crime he didn't commit and has to prove his innocence from within the prison. Sasuke is also a likely candidate. His brooding and sometimes anti - social nature could lead to him getting into trouble with the law in a fanfiction setting. Another one could be Orochimaru. Given his history of unethical experiments, it's not hard to imagine him ending up in jail in a fan - created scenario.
Sasuke would definitely be one of the main characters to interact with Naruto. Their relationship has always been complex, and with Naruto as a girl, it could become even more so. Sakura would also interact a lot. She might be both jealous and intrigued by Naruto's new form. Kakashi too, as Naruto's mentor, would have to adjust to this change and guide 'her' in a different way perhaps.
One of the likely supporting characters is Tsunade. Given her experience and leadership in the village, she could be a source of advice for Naruto and Hinata. She might also ensure that Hinata has the best medical resources available during her pregnancy. Rock Lee could be another supporting character. His positive attitude and loyalty to Naruto would make him eager to help out. He could be running errands for them or helping with any physical tasks. And Neji, if he were still alive in this fanfiction, would surely be there to protect his cousin Hinata and support Naruto as well.
Kakashi could also be an important character. He has a lot of experience and wisdom. When Naruto gets high, Kakashi might be the one to guide Naruto through this strange state, using his own past experiences and knowledge of different ninja techniques. And then there's Jiraiya. Given his relationship with Naruto, he would surely be involved, perhaps trying to use his own unique jutsu to help Naruto come back to normal.