Another plot could involve the Quincy from Bleach. Uryu could be mistaken for a Devil by some of the Highschool DxD characters because of his unique powers. This misunderstanding could lead to a conflict at first, but then they realize they are all on the same side against a greater threat, like a powerful fallen angel who is trying to start a war between the Hollows, Devils and Quincies.
One interesting plot could be the characters from Highschool DxD somehow ending up in the Bleach universe. Maybe Issei and his friends are mistaken for Hollows due to their demonic energy and are hunted by Soul Reapers. They then have to prove their innocence while also learning about the complex spiritual world of Bleach.
Another interesting concept could be a character swap. Imagine Ichigo from Bleach attending the school in Highschool DxD. How would he interact with the devils and other supernatural beings there? He might use his Soul Reaper powers in unexpected ways within the Highschool DxD universe.
One possible plot twist is that the hogyoku from Bleach somehow ends up in the hands of a character in Highschool DxD. This could lead to a character attempting to use it for their own gain, perhaps to gain ultimate power over both the devils and the angels. Another interesting plot twist is that a character from Highschool DxD gets reincarnated as a Soul Reaper in Bleach. They would have to learn the ways of the Soul Reapers while still retaining some of their previous abilities and memories. This could create some really interesting character development. A third plot twist could be that the balance between the three factions in Highschool DxD (devils, angels, and fallen angels) is disrupted by the arrival of Hollows from Bleach. The factions would have to figure out how to deal with this new threat, and it could lead to some unexpected alliances.
Perhaps Natsu's presence could disrupt the balance between the three factions in the Highschool DxD world. His strong sense of justice might lead him to oppose some of the more underhanded dealings among the devils, angels, and fallen angels. This could start a chain of events where he has to prove himself and his beliefs to the various characters.
One idea could be that Inuyasha gets transported to the world of Highschool DxD. He might mistake the devils and angels there for demons from his own world and start attacking them. This would create chaos and also lead to some interesting alliances as the characters from Highschool DxD try to figure out who he is and why he's there. Another plot could involve a shared enemy. Maybe a powerful demon from Inuyasha's world somehow makes its way to the Highschool DxD universe and starts causing trouble for both groups. They would then have to combine their powers and knowledge to defeat it.
Well, there could be a plot where the Sacred Gears in Highschool DxD are somehow connected to the ninja powers in Itachi's world. Itachi discovers that some of the students with Sacred Gears have a latent ninja ability within them. He then decides to train these students to help them control and enhance their powers. In return, the students of Highschool DxD help Itachi understand the complex social and power dynamics of their world, which is very different from his own.
One idea could be to have the characters from High School DxD cross over into a world ruled by different gods. They could be tasked with a quest to restore balance. For example, Issei could use his Boosted Gear in a realm where the gods' powers are waning and his power might be the key to saving the day.
A cool plot idea could be a tournament where characters from both Highschool DxD and Naruto participate. The ninjas would show off their jutsu and the devils would display their powers. Also, imagine if Naruto got a Sacred Gear. He could use it to enhance his Rasengan or even create a new jutsu that combines his ninja abilities with the power of the Sacred Gear. Or perhaps, the female characters from Highschool DxD like Rias could teach some of the kunoichi in Naruto about different ways of using their femininity as a power, which could lead to some interesting character development for the kunoichi.
One idea could be that Ichigo is somehow transported to the High School DxD world and has to deal with the Devils and Angels there. He might use his Soul Reaper powers in unique ways to solve the problems in this new world.
Perhaps there could be a crossover of the two schools. The students from Beacon Academy and Kuoh Academy could have an exchange program. Yang might get into some friendly (or not so friendly) competitions with the devils in terms of strength, while Weiss could be fascinated by the more formal and complex social structure in the Highschool DxD world.