For her family, it could be a shock. Her parents might feel sad and regretful that they didn't have a closer relationship with her so that she could confide in them. Her siblings might also be affected, perhaps feeling a sense of loss or confusion.
For Harry, it could be a huge emotional blow. Sirius was like a father figure to him. His running away might make Harry feel abandoned again, and it could also fuel his determination to find out the truth and bring Sirius back.
Spike would be heartbroken. He's like Twilight's little brother. He depends on her for guidance and love. If she runs away, he might try to find her on his own and in the process, grow up a bit as he faces challenges alone. He could also feel abandoned and struggle with his own self - worth.
It could make Batman more determined to find him. Batman would be worried about his safety and would start an intense search. He might also feel guilty, thinking that he could have done something to prevent Tim from running away.
For Aunt May, it would be a huge shock. She has already lost so much in her life, and Peter running away would make her feel like she has failed in some way as a guardian. She would probably be constantly looking out the window, hoping to see him come back home. Also, the villains in the story could see his absence as an opportunity. They might become more bold and start causing more chaos in the city, knowing that Spider - Man is not around to stop them.
His friends will surely be worried. They might start looking for him everywhere, feeling sad and confused about why he left. For his closest friends, it could be a very emotional time as they fear for his safety.
For Sasuke, Naruto's departure could be a wake - up call. He might realize how much Naruto actually meant to him and the village. It could make him re - evaluate his own goals and actions, perhaps leading him to try and find Naruto to bring him back.
Well, it could create a sense of panic. Since Harry is seen as a symbol of hope against the dark forces, his departure might make people fear that the balance is tipping towards the dark side again. It might also lead to a power vacuum as he was often at the center of many important events and battles.
She could also be running away to protect the baby. There might be some sort of danger or negative influence in her current place. For example, if there are people who would harm the baby or if the society she lives in is very judgmental towards unwed mothers.
It could cause a sense of loss. Harry is a symbol of hope for the wizarding community. His running away might make some people feel abandoned.
It could make them realize how much they've taken her for granted. They might have been so focused on their gifts and their own roles that they didn't notice Mirabel's pain.