Palpatine could still be the main antagonist even if Luke turns to the dark side. He might try to use Luke as a more powerful weapon against any remaining Jedi or the Rebel Alliance. Palpatine would see Luke's newfound dark side power as a means to further his own control over the galaxy.
It could be Vader himself. Even though he's Luke's father, if he believes that Luke turning to the dark side is the only way for them to be truly united as a family, he could become the antagonist in the sense that he actively encourages Luke's descent into darkness, all while thinking it's for the best.
It could be a new Sith Lord created specifically for the fanfiction. This new character could be more powerful and devious than any before. He could be the one who lures Luke to the Dark Side and then becomes his enemy as they compete for power within the Dark Side hierarchy.
It could be the remaining Jedi. Since Luke is turning to the dark side, the Jedi who still uphold the light side values would be against him. They would see him as a threat to the balance they are trying to maintain and would try to stop him from fully embracing the dark side.
It could be Darth Sidious. He is always looking for powerful allies. If he senses Ahsoka's potential and her growing disillusionment with the Jedi, he might manipulate her into joining the Dark Side. His cunning and power would make him a formidable antagonist in this scenario.
It could be an existing villain from the original story who sees Adrien's potential and manipulates him into turning to the dark side. For example, a powerful sorcerer or a mastermind criminal. They could use Adrien's weaknesses, like his desire for power or his need to prove himself, against him.
It could be the remaining Jedi. Since Luke has joined the dark side, the Jedi who still uphold the light side would be his natural antagonists. They would see him as a threat to all they stand for and would try to stop him from spreading the influence of the dark side. For example, Leia, if she still adheres to the Jedi teachings, would be in direct opposition to Luke.
It could be Sasuke. If Sasuke continues to pursue his own vendetta in a more extreme way and Naruto's attempts to bring him back fail, Sasuke could become the main antagonist. Their rivalry could turn into a full - blown battle for power and ideology, with Naruto being pushed to his limits and potentially turning dark in the process of trying to stop Sasuke.
It could be an ancient dark wizard who has been manipulating events from the shadows. This wizard might see Elsword as a powerful tool and has been slowly influencing him to turn dark. The wizard could be using dark magic to cloud Elsword's mind and make him more susceptible to negative emotions.
It could be Dumbledore. If Harry turns to the Dark Side, Dumbledore, who has always been a guiding figure for Harry, would be the main one to oppose him. Dumbledore represents the light and everything Harry is now against. Dumbledore would try to stop Harry from causing chaos and destruction in the wizarding world.
It could be a new, powerful dark side user created specifically for the fanfiction. This character might have a vendetta against the Skywalker family and sees turning Leia as a way to get revenge on Luke and Anakin. They could use Leia's insecurities and her desire to protect her loved ones against her.
It could be a long - lost moon - dwelling ninja clan that has a grudge against the Leaf Village. They see Naruto as a threat to their plans on the moon's dark side.