Ash is the central figure even when he's a baby. Then there's Misty and Brock. They would be major characters as they are Ash's friends and would be the ones to take on the responsibility of looking after baby Ash. Also, Team Rocket, Jessie, James, and Meowth could be significant as they might try to take advantage of Ash's situation or end up helping in an unexpected way.
Obviously, Ash would be a main character even in his baby form. Pikachu is bound to be a key character as well, being Ash's closest Pokémon partner. His other Pokémon like Bulbasaur, Charmander, and Squirtle could also play important roles in protecting and taking care of baby Ash.
Obviously, Ash would be one of the main characters since he's the one who turns into a Pokémon. His Pokémon partners like Pikachu would also be important. They might be confused at first about Ash's transformation but then help him adapt. And if we consider the 'lemon' as something non - adult related, there could be a new character, perhaps a wise old Pokémon that has some knowledge about Ash's transformation and guides him through this strange new phase.
Obviously, Shadow himself would be a main character even in his baby form. Sonic would also be a key character as he is often the hero in these Sonic - related stories. He would likely be involved in trying to figure out how to turn Shadow back. Tails could be another main character as his intelligence would be useful in finding a solution to Shadow's transformation. He might study the cause of it and try to come up with a remedy.
Well, perhaps it could be about a magical event that causes Ash to transform into a baby. Then his friends have to take care of him while also trying to find a way to reverse the transformation. Maybe Pikachu has to protect baby Ash from other Pokémon who might mistake him for an easy target.
Mario would definitely be a main character. Since Luigi is his brother, he would be the one most concerned about Luigi's transformation and would do everything he could to help him. Princess Peach could also be a main character. She might offer her castle as a safe place for baby Luigi and use her resources to find a solution. Toad could be there too, helping Mario with taking care of Luigi and providing useful information about the kingdom that could lead to reversing the spell.
Perhaps a mysterious stranger. This stranger could have some connection to the reason why Edward turned into a baby. And then there's Edward's pet dog. The dog might be confused at first but then becomes very protective of baby Edward, adding an interesting dynamic to the story.
Her best friend could be a main character. They might be the one who is most affected by her transformation and has to take on a lot of responsibility in taking care of her.
Erza could also be a main character. Given her strong and motherly side, she would probably take on the role of taking good care of baby Lucy. She might be strict about following a routine for baby Lucy's care. Happy, the flying cat, could be another important character. He could use his unique abilities to search for clues on how to turn Lucy back to normal.
His guildmates would surely be main characters. For example, Natsu could be there. Natsu might be really confused at first but then would be super protective of baby Laxus. Another could be Lucy. She might be the one who is more practical in taking care of the baby, like making sure he has proper clothes and a comfortable place to sleep.
In addition to the usual suspects, there could be some new characters introduced. For example, an old Pokémon trainer who has seen similar things before and can offer some advice on how to deal with baby Ash. Or a mysterious Pokémon that has the power to either help or hinder the process of getting Ash back to normal.
A new villain could be a powerful and dark psychic - type Pokemon. This Pokemon could have the ability to turn Ash into a Pokemon as part of its grand plan to take over the Pokemon world. It sees Ash, who has always been a symbol of hope and a strong trainer, as a threat even in his human form. So, by turning him into a Pokemon, it hopes to disrupt the balance and order that Ash has been a part of maintaining.