Obviously, Ash would be the main character. Then there could be female characters who form his harem. Maybe some of his long - time friends like Misty and Brock could also be involved in some way, even if they are not part of the harem directly. There might also be new characters that he meets during his disappearance.
Well, it could be that Ash disappears on a dangerous quest. His friends in the harem are distraught. When he returns, he might have new powers. And then he has to deal with the changed dynamics in the harem, like some might be angry at him for leaving, while others are just overjoyed to have him back.
Definitely Pikachu. It's Ash's closest companion, so it could be part of the harem in a very unique way. Then there could be female Pokémon trainers like Misty and May. They have a history with Ash and could be part of this harem concept.
Some fanfictions might have Misty betray Ash. Perhaps she gets lured by the promise of power or some valuable reward. She could be tricked into believing that Ash is no longer the friend she thought he was and that betraying him is for the greater good.
The setting in which Harry disappears and returns also matters. If it's in the middle of Hogwarts, the school would be in chaos. Teachers would be trying to keep the students calm while secretly searching for Harry. And when he returns, the reactions of different houses - Gryffindor being relieved and proud, Slytherin perhaps being suspicious - could add more layers to the story.
Obviously, Alexis and Castle would be the main characters. Their relationship as father and daughter is central to the 'Castle' series, so in this fanfic, their dynamic would be crucial. Castle would be the one trying to find Alexis, and Alexis would be the one in the middle of whatever situation led to her disappearance.
Gary Oak is a likely character. He has always been a rival to Ash and in fanfiction, he might betray Ash out of jealousy or a desire to be the ultimate Pokémon trainer. Another could be Misty. Maybe she gets influenced by some external force or her own insecurities and turns against Ash. Brock could also be a candidate in some stories. If he falls in love with a girl who has a vendetta against Ash, he might be forced to choose between his loyalty to Ash and his new love interest.
Naruto is definitely one of the main characters. He is the key figure in the Naruto universe. His family, which includes Hinata, Boruto, and Himawari, are also likely to be main characters. Boruto, with his own dreams and potential, might be facing some internal or external conflicts. Himawari, being the younger one, could be used to show the family's protective side. And of course, other characters from the original series like Sasuke might also make appearances, as he is Naruto's best friend and they have a deep connection.
Obviously Naruto himself. Then Sasuke would probably be involved as they have a deep connection. Sakura too, since she's part of their team. Kakashi might also play a role as Naruto's former teacher.
Obviously, Ash and Greninja are the main characters. Ash, the trainer with a big heart and a lot of determination. Greninja, the powerful and unique Pokémon with its cool design and amazing abilities.
In certain fanfictions, a Pokémon professor or an authority figure in the Pokémon world could betray Ash. They may have their own secret agendas. For example, a professor might use Ash's research data without his permission or manipulate him into dangerous situations for their own experiments. This would make Ash feel extremely betrayed as he looks up to these figures for guidance.