In some cases, the antagonist could be Esme herself, or rather a version of her from the past. The past Esme might be more naive or self - centered and not understand the implications of Esme's actions in the past. The present Esme is trying to make positive changes, but the past version of herself keeps getting in the way, either through her own actions or by influencing the people around her in a negative way.
One possible plot could be that Esme travels back to a time when she was about to make a crucial life decision. For example, she might go back to the moment before she met her significant other. In the past, she could then have the chance to see things from a different perspective. Maybe she realizes that the decision she made back then was actually the best one, or she might find out new things about herself or the people around her that she didn't know before, which could lead to a whole new set of adventures and self - discovery in the past and ultimately change her view of her present life.
It could be a time - traveling version of Zeref. He might be trying to stop Natsu from changing things in the past that could potentially lead to his own downfall in the future.
It could be a time - traveling pirate who has his own evil plans for the past. He might be trying to change the past to gain ultimate power in the future. So he becomes an obstacle for Luffy who wants to either preserve the past or make positive changes.
Danzo could still be a major antagonist. Even if Naruto travels back in time, Danzo's thirst for power and his underhanded methods would still pose a threat. Naruto would have to find a way to deal with him without causing too much chaos in the village.
It could still be Orochimaru. Even if Sasuke travels back in time, Orochimaru's thirst for power and knowledge wouldn't change. He would still be plotting to gain power, and Sasuke, with his knowledge of Orochimaru's future actions, would be in a position to stop him. Orochimaru's experiments and his desire to take over the bodies of others make him a formidable antagonist.
Aizen could still be the main antagonist. Even if Ichigo travels back in time, Aizen's long - term plans might be already in motion. Ichigo would have to find a way to expose and stop Aizen earlier than in the original timeline.
She could meet the founders of Hogwarts. Imagine Hermione having a conversation with Rowena Ravenclaw about the importance of knowledge and wisdom. She might also meet Godric Gryffindor and learn about the true meaning of courage from him. Another person she could meet is Salazar Slytherin. It would be very interesting to see how she would interact with him, given his views on blood purity.
Cell could be a great antagonist. Even if Gohan goes back in time, Cell might still find a way to exist. Maybe he adapts his plan to absorb the Androids earlier in time. Gohan would then have to face a more powerful and unpredictable Cell, who could potentially change the timeline to his own advantage.
Frieza would be a great antagonist. If Goku goes back in time to a point before Frieza was defeated, Frieza could be an even more menacing force as Goku might not have all the power - ups he had in the original timeline. He'd have to rely on his wits and basic training more.
In some cases, it could be other time - traveling vampires or supernatural beings who have their own agendas. They might not want Bella to interfere with the past as it could disrupt their own plans or power bases. These antagonists could be more shadowy figures, working behind the scenes to thwart Bella's efforts.