It could be a long - lost Uchiha with powers beyond that of Madara. This Uchiha could have been in hiding, gathering power and knowledge, and his ultimate goal is to reshape the world in his own dark image. Naruto realizes that the only way to stop him is by sacrificing himself.
Maybe an ancient demon that was sealed away centuries ago has been released. This demon is so powerful that it starts to corrupt the world and turn it into a hellish place. All the combined efforts of the ninja forces are not enough, and Naruto, being the hero, decides to sacrifice himself to seal the demon away again, knowing that it's the only hope for the world.
A rogue group of ninjas who have mastered a forbidden jutsu that allows them to control the very fabric of reality could be the main antagonists. They use this power to cause chaos and destruction, and Naruto finds out that he can sacrifice his own life to disrupt the jutsu and end their reign of terror. He chooses to do so to protect the innocent people and the future of the ninja world.
Well, it could be that Naruto sacrifices himself to seal away a dark and ancient curse that is threatening to destroy not only the ninja world but all of existence. He realizes that his unique connection to the tailed beasts and his strong willpower make him the only one who can perform this self - sacrificing sealing jutsu. So, he says his goodbyes to his friends, family, and the village he loves and gives up his life to save everyone.
It could be a new and extremely powerful ninja from a far - off land who has a vendetta against Konoha. His power might be so great that Naruto decides the only way to stop him in the long run is to seal himself away as a sort of trap for when the antagonist gets too close to achieving his goals.
It could be an evil version of Sasuke. Maybe he has fallen completely to the dark side and manipulates Naruto into destroying Konoha. Or it could be Orochimaru who has found a new way to control Naruto's actions from the shadows.
Perhaps in the fanfiction, Naruto gives his life energy to Boruto to save him from a deadly curse. Boruto then has to deal with the newfound power within him, which is a mix of his own and his father's. He may struggle to control it at first but eventually learns to use it for good. This could also lead to a rift between Boruto and some of the villagers who blame him for Naruto's death.
One possible plot could be that in a final battle against an extremely powerful enemy, Naruto realizes that the only way to save Hinata and the entire village is by using a forbidden jutsu that will cost him his life. He makes this sacrifice with a smile on his face, knowing that Hinata and the others will be safe. Hinata is heartbroken but also determined to carry on Naruto's legacy of protecting the village.
It could be Orochimaru. He's always been interested in unique powers and abilities. The idea of X - 23's mutant abilities and Naruto's jinchuriki powers would be very appealing to him. He might try to capture them both to use in his experiments to gain ultimate power.
A new character could be created as the antagonist. For example, an Uchiha who has been corrupted by the power of the Sharingan and wants to use Naruto's special Uchiha - related abilities for his own evil purposes. This character could be jealous of Naruto's unique position within the Uchiha - related story and try to take it from him.
It could be a rogue ninja who has mastered parkour to an extreme level. He uses his skills to steal important ninja artifacts and Naruto has to stop him. This antagonist would be very fast and agile, making it difficult for Naruto to catch him using normal ninja techniques.
Madara could still be the main antagonist even in a 'naruto bankai fanfic'. He senses Naruto's new power and realizes it could be a threat to his plans of world domination. He adapts his strategies and attacks Naruto with all his might, trying to prevent Naruto from fully mastering and using his Bankai - inspired power to its fullest potential.
A powerful and corrupt ninja from another village could be the main antagonist. He hears about the unique knives in Naruto's village and decides to steal them to increase his own power and the dominance of his village. He would stop at nothing to get his hands on these knives, even if it means starting a war between the villages.