It would likely make Naruto's relationships with female characters more complicated. His sister's overprotectiveness might make it difficult for him to develop romantic relationships. For instance, if a girl shows interest in Naruto, his sister could interfere and scare the girl away.
However, on the positive side, it could also strengthen some relationships. Some of Naruto's friends who understand the situation might be more empathetic towards him. They could help Naruto deal with his sister's complex, and in the process, their friendship could become deeper. For example, Shikamaru, being the intelligent one, might come up with strategies to handle Naruto's sister without causing too much conflict.
It could also strain his friendships with male friends. His sister might see his male friends as a threat to her special bond with Naruto. For example, if Naruto's friends want to go on a boys - only adventure, his sister could try to stop them, causing tension between Naruto and his friends.
The sister's complex can also be a source of character development for Naruto. He might start to realize how much his sister depends on him and feel responsible for her in a different way. This could lead to him becoming more empathetic and patient. He might have to balance his own goals and dreams with his sister's need to be close to him all the time.
With his friends like Sakura and Kakashi, they would be very curious. Sakura might try to study Naruto's Pokemon bloodline to understand how it works. Kakashi, on the other hand, would be more focused on how to train Naruto to control these new powers. It could bring them closer as they all try to figure out the implications of this new development in Naruto's abilities.
The adopted sister could actually strengthen Naruto's relationships. She could bring a new dynamic to their group. Naruto would be more responsible as he has someone else to look after. His friends would see this growth in him and respect him more. They might also start to include the sister in their activities, like inviting her to training sessions or parties, which would further integrate her into their circle.
Well, it could make him more emotional. He would be more easily affected by his sister's actions or situations. For instance, if his sister is sad, Naruto might be extremely downcast himself.
His relationship with his friends in Konoha would also change. They would look at Naruto in a new light, with a mix of awe and pride. Naruto might become a bit more of a leader figure among them, as his new power would make him stand out even more. However, he would still be the same Naruto at heart, so he would have to make sure not to let the power go to his head and alienate his friends.
His relationship with Sasuke might change. Sasuke always saw Naruto as a strong rival, and a big part of Naruto's strength was Kurama. Without Kurama, Sasuke might view Naruto differently. Also, Naruto's friends might be more protective of him, as they know he's lost a major source of power.
The cat could make Naruto more approachable. His friends might be drawn to the cat and start spending more time with Naruto because of it. For example, Sakura might see Naruto's kindness towards the cat and start to view him in a new light, strengthening their friendship.
Well, Naruto's personality is all about making friends and believing in people. So in Sasuke's body, he'd probably reach out to some of Sasuke's loner - type friends. For instance, he might be able to get closer to Sai in a different way. Sai, who is used to Sasuke's coldness, would be met with Naruto's warmth. And when it comes to Sasuke's family - related relationships, Naruto could bring a new perspective. He might try to heal some of the rifts within the Uchiha clan's remaining members with his 'never - give - up' spirit.
With Sasuke, things could get more complicated. Sasuke might see Naruto's new bloodline as another way Naruto is getting stronger while he struggles to reach his own goals. This could fuel their rivalry even more, or it could lead Sasuke to try and understand Naruto's new situation in an attempt to gain an edge himself.
Well, one possibility is that the sister constantly tries to protect Naruto from any harm. She might get overly jealous of any girl who shows interest in him. For example, if Hinata were to approach Naruto, the sister could interfere in a rather possessive way.