It could be a new character created just for the fanfiction. Maybe a rogue ninja who has mastered a dark and powerful jutsu that Naruto has no defense against. This antagonist could be seeking revenge on Konoha for some past wrong and sees Naruto as the biggest threat to his plans.
The Akatsuki could be re - formed with even more dangerous members. They might target Naruto specifically because of his status as a Jinchuriki and a powerful ninja. Their combined efforts and devious plans could ultimately lead to Naruto's downfall in battle.
An old enemy could return in a more powerful form. For instance, Orochimaru could come back with enhanced powers and a new army of experimental creatures. Orochimaru has always been obsessed with power and immortality, and Naruto might stand in his way during his new quest for domination, leading to a fatal battle.
It could be someone who was secretly behind Naruto's death in the first place. Maybe a rogue ninja who has a vendetta against the Hidden Leaf and saw Naruto as a major obstacle.
It could be an ancient evil that was sealed away long ago but has been released due to Naruto's death. Maybe Naruto's sacrifice in his previous life weakened the seal, and now this evil has emerged. It could be a powerful demon or a dark ninja with extremely strong and malevolent jutsu.
It could be Orochimaru. Since Naruto was a potential threat to his plans in the original story, if Naruto died as a baby, Orochimaru might be able to carry out his experiments and schemes more freely without having to worry about Naruto interfering in the future.
It could be an unknown shinobi from a far - off land. A shinobi with powers that Naruto has never encountered before. This new antagonist might have some dark and powerful jutsu that Naruto simply isn't prepared for, which ultimately leads to his downfall on the bridge.
A rogue ninja from another village could be the main antagonist. Maybe a ninja from the Hidden Mist Village who has a personal grudge against Konoha and sees Naruto as the symbol of Konoha's strength. So, he devises a complex plan to take down Naruto. This ninja could have some unique and deadly jutsu that Naruto has never faced before, which ultimately leads to his downfall.
It could be a long - lost relative of one of the old villains like Orochimaru. Maybe this person has been in hiding, training and growing in power, and now wants to take revenge on Konoha for what happened to their family member.
It could be a rogue ninja who has mastered a forbidden jutsu and wants to destroy the village out of revenge. Naruto would then have to face this extremely powerful foe and in the end, sacrifice himself to stop the destruction.
Perhaps a new, unknown force. With Naruto gone, a previously hidden group with a vendetta against the ninja villages could emerge. They might blame the villages for the destruction caused during the war and see Naruto's death as the perfect time to strike, when the villages are still recovering and vulnerable.
The warden of the Blood Prison could be the main antagonist. He might be a power - hungry and corrupt individual who sees Naruto as a threat to his control over the prison. So, he devises plans to get rid of Naruto, which ultimately lead to Naruto's death.
Madara Uchiha might be the main antagonist. He has grand plans for the ninja world. He could see Naruto as a threat to his vision and engineer a situation in the Valley of the End where Naruto is killed, either directly or by using Sasuke as a pawn.