There could be injured ninjas from battles. They would come to Naruto's clinic to get healed.
Maybe even some of the antagonists from the original Naruto story could become patients. Naruto's kind heart would lead him to heal them too, and this could be a chance for their redemption. For example, someone like Zabuza could be brought to the clinic severely injured, and Naruto would see it as an opportunity to show mercy and change the person for the better.
Ordinary villagers would also be patients. They might have normal illnesses or injuries from their daily lives. Naruto would treat them all with equal care, just like how he protected the village.
In this fanfiction, Naruto could also face challenges in running the clinic. He might struggle with administrative tasks since he's used to the action - packed ninja life. But he could hire some of his ninja friends to help, like Sakura as a medical expert and Rock Lee to handle the physical tasks around the clinic.
He could meet some of Iwa's powerful ninjas. Maybe Onoki, who could either see him as a threat or an opportunity. There might also be some young Iwa ninjas who are curious about Naruto and his abilities.
He might meet some of his distant Uzumaki relatives. There could be elders or other Uzumaki clan members who have valuable knowledge about his family and their special abilities.
Sasuke could be one of the people to help. Despite their past differences, Sasuke has a deep connection with Naruto. He might be able to understand Naruto's situation and offer his protection and support.
He would surely meet Gaara. Gaara has had his own struggles and he might be able to understand Naruto on a deeper level. They could form an even stronger bond than before, with Gaara helping Naruto hide from those who might be looking for him in Suna.
The orphans themselves would be main characters. Each one could have their own backstory and personality. Some might be shy, while others could be more outgoing. They would be the ones directly affected by Naruto's care and teachings.
Sakura might try to stop Naruto. She is one of his closest friends. She cares about him deeply and would be worried about his safety. Also, she would understand that running away is not the best solution to whatever problems he is facing.
He could meet some rogue ninjas. These ninjas might either try to harm him or, in some cases, offer to help him on his journey. They might have their own reasons for being in the area between Konoha and Kumo.
Mal might meet a group of outcasts like herself. They are all running from different problems but have formed a kind of family. Together, they teach Mal the importance of community and support, and they all help each other face the challenges that come their way.
There's a chance he'll meet other lost souls, people who are also on a journey of self - discovery. They could be from different villages and have their own reasons for being in the area. Naruto's positive attitude and determination might inspire them, and they could end up traveling together towards Uzu, sharing their stories and skills along the way.