Another option could be Naruto and Kaiba. Kaiba is a very proud and powerful character in Yugioh. He might initially view Naruto's situation of being neglected as a sign of weakness. But as the story progresses, he could see Naruto's determination and strength. Their interactions could be full of clashes at first, but then they could find common ground in their pursuit of power and recognition. Naruto would be trying to regain his status among his peers, and Kaiba would be constantly aiming to prove himself as the best duelist.
Naruto and Joey Wheeler could also be main characters. Joey is a very friendly and empathetic character. He would be more likely to quickly understand Naruto's pain of being neglected. They could bond over their shared experiences of having to prove themselves. Joey could introduce Naruto to the world of Yugioh duels, and Naruto could teach Joey some ninja skills. Their friendship could be the heart of the fanfic as they both work towards helping Naruto overcome the neglect he has faced.
One possible plot could be that in a crossover world, Naruto is somehow neglected by his usual friends and allies. Meanwhile, a Yugioh character, perhaps Yugi, stumbles into this world. Yugi notices Naruto's situation and decides to use the power of the Millennium Puzzle to help Naruto regain his confidence and the respect of those around him. They form an unlikely friendship and together face challenges that the neglect has caused, like Naruto having to prove himself all over again in battles.
Sonic would be a main character for sure. Then there could be other Naruto characters like Sasuke and Sakura. Sasuke might be so focused on his revenge and training that he doesn't give Sonic a second thought. Sakura could be too caught up in her medical ninjutsu studies and her feelings for Sasuke. So Sonic is left in a world where these important characters are basically ignoring him, which makes for an interesting dynamic.
Another option for the main characters could be Kaiba from Yugioh. His pride and determination would make for an interesting dynamic when faced with the neglect from the Naruto world. And from Naruto, Sasuke could be involved. He might initially see the Yugioh characters as a distraction from his own goals, but later on, things could change.
One possibility is to make the maiden a mysterious girl who has the power to sense the emotions of duel monsters. She meets Bastion Misawa and is intrigued by his logical approach to dueling. As they interact more, she falls in love with him. Or, we could have a maiden who is a relative of a well - known duelist in the Yugioh GX world. She comes to the school to visit and ends up falling in love with Syrus Truesdale, who is initially very shy around her.
Iruka could also be important. Iruka was one of the first people to show Naruto kindness. If in the fanfic Iruka somehow fails to support Naruto or if there is a rift between them, it could be a factor in Naruto's departure. For example, if Iruka is forced to take a side against Naruto due to village politics.
I think Tsunade could be a main character in a 'naruto himekishi fanfic'. Given her strength and leadership, she could be in charge of the himekishi in the Hidden Leaf Village. Another possible main character could be Rock Lee. His hard - working and determined nature would fit well with the concept of the himekishi. And of course, Sasuke could also be involved. Maybe he has a complex relationship with the himekishi, either as an ally or an antagonist depending on the story's direction.
Obviously, Naruto could be one of the main characters. He could be either a patient or someone helping out at the hospital. Another main character could be Sakura. Since she has medical skills, she could be a doctor or a medic - ninja in charge at the hospital. And then there could be a new character, like a young orphan who is being trained as a medic - ninja at the hospital and has an interesting backstory.
In a 'Naruto of the Sand' fanfic, the main characters could be Kankuro. He has his own unique puppet - using abilities and his relationship with his siblings and the Sand Village could be explored. Another main character could be the Kazekage at the time of the fanfic's setting. Their leadership and decisions would impact the story greatly. Also, Shukaku could be a main character in a sense. Since it is related to Gaara and has a powerful presence, its influence on the events in the Sand Village could be an interesting aspect to write about.
Obviously Naruto himself could be a main character. His determination and never - give - up attitude would be key in facing the Eldrazi threat. Sasuke could also be a main character, his powerful Sharingan and combat skills would be useful in battles against the Eldrazi.
I think Naruto and Itachi could also be main characters in this fanfic. Naruto might look up to Itachi for his self - sacrifice and powerful abilities. Itachi could act as a mentor - like figure to Naruto in the context of the fanfic, guiding him in understanding the Uchiha clan better.