The Akatsuki members might also have a complex reaction. Some, like Itachi, might see it as a waste of a great potential. Others, like Pain, who had once fought Naruto, might feel a strange sense of respect for Naruto's sacrifice. The ninja animals that were associated with Naruto, like the toads from Mount Myoboku, would mourn his loss. They would probably wonder if there was something they could have done to prevent his death and feel a sense of duty to protect the Hidden Leaf in his memory.
Sasuke would be deeply affected. He and Naruto had a complex relationship, from being rivals to friends. He would likely feel a sense of guilt, as if he should have been there to protect Naruto. Sakura would be heartbroken. She had always cared for Naruto, and seeing him die in such a tragic way in front of his parents would make her feel helpless. His parents, on the other hand, would be in utter despair. His father might feel like he failed as a father again, not being able to protect his son this time either.
The characters in 'Naruto' would be deeply affected if Naruto dies at birth in fanfiction. Jiraiya would be one of the most affected. He saw Naruto as his protege and the hope for the future. Without Naruto, Jiraiya might lose his enthusiasm for training and spreading his teachings. Tsunade would also be saddened as she had a connection to Naruto through her relationship with Jiraiya and Minato. The Rookie 9, Naruto's friends, would have a completely different dynamic. They might not form as tight a group without Naruto's energetic and positive influence. And the Sannin, as a whole, would have their relationships and legacies altered without Naruto in the picture.
He would be filled with rage. Naruto has a strong sense of justice and the fact that someone took Hinata away from him would fuel his anger. He would vow to find and punish whoever was responsible. He might even become reckless in his pursuit of vengeance, endangering himself and those around him. His friends would have to step in to try and bring him back to his senses.
Hinata would be in shock. She'd probably freeze for a moment, unable to believe what she's seeing. Her eyes would be wide open in horror.
Perhaps Naruto is poisoned by a powerful new villain. His parents are revived just in time to see him succumb to the poison. This event could trigger a series of events where his friends and the entire village vow to avenge his death. His parents might then decide to stay in the living world to help in this quest for vengeance, despite the rules of the afterlife.
For Hinata, it would be a crushing blow. She loved Naruto so much. She might withdraw into herself at first, overcome with grief. But then, she could find the strength within herself to carry on Naruto's legacy, especially for their son, Boruto (if in a post - Naruto - has - a - family scenario in the fanfiction). Shikamaru, being Naruto's friend, would feel a deep sense of loss. He would use his intelligence to try to figure out what led to Naruto's death and if there was any way to prevent it in hindsight. And the other members of the Leaf Village would be in a state of shock and mourning. Naruto was their hero, and his death would make them question their safety and future without him.
Naruto might also try to remember Sakura in a positive way. He would cherish the memories they had together. He could start initiatives in the village in her name, like promoting medical ninja training more, since Sakura was a great medical ninja. He would slowly turn his grief into a force for good in the village.
Sasuke would be deeply affected. He and Naruto had a complex relationship. His first reaction might be shock and then a deep sense of loss. He might feel guilty for not being there to help Naruto. Sakura would be heartbroken. She had always cared for Naruto, and his death would be a huge blow. She might become more determined to protect the village in his memory. And Boruto, Naruto's son, would be devastated. He would probably grow up with a strong sense of purpose to live up to his father's sacrifice and protect the village even better.
Tsunade herself would be in a state of shock and deep remorse. She might blame herself for Naruto's death, thinking that she should have been stronger and not needed saving. The villagers would also be greatly affected. The children who looked up to Naruto as a hero would be heartbroken. They would start to tell stories about his bravery, and some might even be inspired to become like him, despite his tragic end.
Sakura would be heartbroken. She would probably blame herself for not being able to protect Naruto. She might also start to train harder to fill the void left by Naruto.
Sasuke would be deeply affected. He and Naruto had a complex relationship. He might feel regret for not being there to help Naruto and also feel a new sense of purpose in avenging his friend. Sakura would be heartbroken. She had always cared for Naruto, and his death would make her question the purpose of the ninja life. Haku herself would be in a state of shock and disbelief. She would feel a heavy burden of guilt, knowing that Naruto sacrificed his life for her. She might become more withdrawn initially but then use Naruto's memory as a motivation to become stronger.