One possible plotline could be that Ash is betrayed by his so - called friends in the Pokémon world. They might spread false rumors about him, making everyone turn against him. Meanwhile, Mewtwo, who has formed an unlikely bond with Ash, is also betrayed by the scientists who created it again. They try to recapture Mewtwo to use it for their evil experiments. Ash and Mewtwo then team up to fight against their betrayers and prove their worth.
Perhaps in this new region, Ash discovers a powerful new Pokemon that others want to control. His friends, fearing the power of this Pokemon, betray him to protect the region. They might think that Ash is being too reckless with this new discovery and that it could lead to destruction. It could also be that there's a prophecy in the new region that Ash is somehow involved in, and his friends misinterpret it and believe he's the cause of potential harm.
One possible plotline could be that Ash's new friends in Galar turn on him due to some misunderstanding. Maybe they think he's trying to steal the spotlight in Pokemon battles. For example, if Ash wins a big tournament that some local trainers had high hopes for. Another could be that a villain in Galar manages to manipulate those around Ash into believing he's a threat to the Galar region. This could be by spreading false rumors about his intentions with powerful Pokemon. Or perhaps there's a new type of Pokemon in Galar that has some sort of mind - controlling ability and it's used on Ash's friends to make them betray him.
One possible plotline could be that Ash and Cynthia are betrayed by a powerful and long - hidden organization in the Pokemon world. Maybe they are lured into a trap under false pretenses. For example, they are told there is a great Pokemon discovery but it's actually a setup to steal their Pokemon or get some important information from them. Another could be a betrayal from a so - called friend. This friend might be jealous of their achievements and decides to side with an enemy to bring them down. This could lead to Ash and Cynthia losing battles they should have won and facing challenges that seem insurmountable at first.
One possible plotline could be that Ash's friends start believing false rumors about him being a traitor to their group. For example, an enemy might spread lies that Ash is secretly working for a rival organization. So, his friends gradually turn their backs on him, leaving him alone and confused. He then has to prove his innocence while also dealing with the pain of betrayal.
One possible plotline could be that Ash discovers May has been secretly working with a rival trainer in order to gain an advantage in a big tournament. This would make Ash feel betrayed as he thought they were friends and training partners. Another could be that May betrays Ash for a rare Pokémon that Ash was also after, choosing the Pokémon over their friendship.
Well, it could be that Hestia betrays Percy for power. In the fanfiction world, she might see Percy as a threat to her own influence among the demigods or the gods. So she makes a deal with another powerful entity to get rid of Percy. For example, she could give false information about Percy's next move to a group of monsters, causing them to ambush him.
One possible plotline could be that Serafall, perhaps influenced by some external force or a misunderstanding, turns on Naruto. Maybe she believes Naruto has some hidden agenda that endangers her or her world. So she starts to undermine Naruto's efforts and even plots against him directly.
It could be that Arceus betrays Ash by revealing that all of Ash's Pokemon encounters and relationships were fabricated. Arceus made it so that Ash would form bonds with certain Pokemon to further its own ends. For instance, Arceus wanted to study the power of friendship among humans and Pokemon through Ash's experiences. When Ash finds out, he feels used and betrayed. He might then set out on a journey to free his Pokemon from Arceus' control and restore their true free will.
One possible motive could be that Mewtwo sees Ash as a threat to its own power or freedom. Ash is constantly on a journey to catch and train Pokémon, and Mewtwo, being a powerful and intelligent Pokémon, might view Ash's actions as a potential danger to its kind or its own existence.
Perhaps in the fanfic, a new and mysterious Pokémon arrives. This Pokémon is able to manipulate the thoughts of those around it. It makes Mewtwo believe that Ash is a threat to all Pokémon. So Mewtwo starts to act against Ash. Ash, on the other hand, is clueless as to why Mewtwo has suddenly turned on him. He has to dig deep into the secrets of this new Pokémon and find a way to reverse what it has done to Mewtwo.