Sasuke's decision could also be related to his growth and redemption arc. He might see Sakura as a symbol of his new start, a connection to the life he wants to lead after all his turmoil. Karin, while having a relationship with him, might not fit into this new vision of his future, so he chooses Sakura instead.
Maybe Sasuke realizes that his relationship with Karin was more of a convenience or based on a misunderstanding. On the other hand, Sakura has always been there for him in her own way, with her unwavering love. He might have finally recognized the depth and purity of Sakura's feelings for him and decided to leave Karin for her.
One possible reason could be his long - standing feelings for Sakura. Despite his journey and time with Karin, his original connection with Sakura might have resurfaced. Sasuke has known Sakura since they were young, and those early memories and emotions could have influenced his decision.
One possible reason could be his strong bond with Naruto. Their relationship has been through so much, and Sasuke might realize that Naruto understands him on a deeper level than Sakura. Maybe he feels that his journey and growth are more intertwined with Naruto's, and he values that connection more in this fanfiction.
Perhaps Sasuke starts to notice Ino's unique skills and how they complement his own. Ino has her mind - related jutsus which could be useful in certain missions or battles. This practical aspect, combined with a growing personal bond, might lead him to leave Sakura for Ino.
There are fanfics like that. Sasuke might leave Sakura for Karin because of Karin's loyalty. Karin has shown unwavering loyalty to Sasuke throughout the series. She was willing to risk her life for him on multiple occasions. In contrast, Sasuke might think that Sakura's love is more of a childhood crush that she hasn't fully grown out of, and he may be drawn to Karin's more mature and selfless loyalty.
One possible reason could be Sasuke's pursuit of power. In many fanfictions, his thirst for greater strength might lead him to leave Sakura behind as he embarks on a solo journey to train in more dangerous and secluded places. He may feel that his goals are too dangerous for her to be involved with.
Karin could be heartbroken. She might initially be angry and feel betrayed, lashing out at Sasuke for choosing Sakura over her.
Sakura might be heartbroken. She's been in love with Sasuke for so long. She could initially go into denial, thinking it's just a temporary thing. Then she might get angry and vow to prove herself to Sasuke, perhaps by becoming an even stronger ninja.
One possible reason in this fanfiction scenario could be that Sasuke feels a stronger connection to Karin on a spiritual or power - related level. Karin has unique abilities that might attract Sasuke more than Sakura's medical ninjutsu. Maybe he sees in Karin a kindred spirit in terms of their past traumas and the way they've had to fight to survive. Also, Karin has always been very devoted to Sasuke, and he might be drawn to that unwavering loyalty.
One reason could be that Sasuke realizes his true feelings for Karin were always there. Maybe in the fanfiction, he had some sort of epiphany that his connection with Sakura was more of a convenience or misunderstanding, while his bond with Karin was deeper on an emotional level.
One reason could be to create drama. The idea of a relationship being broken by cheating is full of emotional turmoil which can make for an interesting read. Another reason might be some writers' preference for the Sasuke - Karin dynamic. They might see potential in their relationship that wasn't explored in the original series.
One possible reason could be that Karin has unique abilities that are more useful to Sasuke in his goals. For example, her sensing abilities might be crucial in his missions. Also, Karin has a deep loyalty towards Sasuke which he might value more than Sakura's feelings at that time.