It could be a rogue ninja who has a vendetta against cats for some strange reason. This ninja might try to capture Tora to use it as bait for Naruto or just because he wants to harm it. So, he becomes the main obstacle in Naruto and Tora's friendship.
Maybe there's an evil organization that believes Tora has some sort of power that they can use for their own dark purposes. They send their agents to capture Tora, and Naruto has to fight against them to protect his new friend. In this case, the entire organization would be the main antagonist.
There could be a jealous villager who doesn't like the fact that Naruto is spending so much time with Tora. This villager might spread rumors about Tora being a bad omen or might even try to harm Tora secretly. And Naruto has to deal with this person's jealousy and malicious actions while trying to keep his friendship with Tora intact.
Well, one possibility is that Naruto helps Tora who might be in some sort of trouble in the village. Maybe Tora got lost outside its usual territory and Naruto uses his ninja skills to find it and bring it back safely. This could lead to a new friendship where Tora starts to follow Naruto around, much to the amusement of the villagers.
There could be a power - hungry shinobi within Konoha itself. He is jealous of the bond between Naruto and Shikamaru and how they are getting stronger together. So, he tries to set them up, making it seem like they are betraying the village. He wants to break their friendship and take their place as a respected ninja in the village.
It could be Draco Malfoy. Since Harry and Ron are not friends, Draco could take advantage of their weakened state. He might try to turn them against each other even more, perhaps by spreading false information about one to the other. He could also try to isolate Harry from the Gryffindor group since Ron is no longer on his side, making Harry an easier target for his bullying.
Sasuke would probably be indifferent at first. He is more focused on his own goals of getting stronger. But if Tora somehow gets involved in a situation that affects Sasuke's plans or if Tora shows some useful skills, he might start to respect Naruto's decision to keep Tora. For example, if Tora helps them track an enemy ninja.
It could be someone from the Naruto universe who doesn't like Naruto's newfound fascination with Aku. For example, Danzo might see Naruto's interest in Aku as a threat to the stability of the village and try to stop Naruto from further exploring Aku - related things. So, Danzo could be the main antagonist in this case.
Maybe a new character could be introduced as the main antagonist. This character could be from a hidden village that has been secretly observing Naruto's growth. They realize his potential as a weapon and plan to steal his power or use him to start a war against other villages.
Krampus himself could be the main antagonist. Since he is a figure known for punishing the naughty, his actions in the Naruto world might be seen as unjust. He could be going after ninjas without really understanding their motives, causing a lot of trouble for the main characters.
It could be a rogue ninja who also has somehow acquired bankai - like powers. This antagonist might be jealous of Naruto's newfound abilities and wants to prove that he is the stronger one. So he starts causing chaos in the ninja world, challenging Naruto at every turn.
It could be a rogue ninja who wants to disrupt Naruto's business to gain power. Maybe he's jealous of Naruto's success and popularity in the business world. He could try to steal Naruto's business secrets or sabotage his operations.
It could be a rogue Kumo ninja who is jealous of Naruto's power and wants to prove himself by defeating Naruto. This ninja might have some dark secrets and a grudge against Kumo as well.