If the spinoff is about the Dothraki, Khal Drogo could be a central character in a pre - Game of Thrones story. We could see his rise to power, his leadership among the Dothraki, and his early encounters with the other cultures outside the Dothraki Sea. Also, there could be a female Dothraki character who challenges the traditional male - dominated hierarchy within the Dothraki society.
Well, if the spinoff is about the early Targaryens, then Aegon the Conqueror would be a main character. He was the one who united most of Westeros under Targaryen rule. Another could be Daenys the Dreamer, as she had the prophetic dreams that led the Targaryens to leave Valyria.
For a spinoff centered on the Citadel, Marwyn the Mage could be a main character. He was an unorthodox maester with a lot of knowledge about magic. And we could also have Archmaester Ebrose, who was involved in some important events in the main series. He could be a key figure in exploring the politics and secrets within the Citadel.
Perhaps a spinoff could tell the story of the Iron Islands from the perspective of the common folk. We could see their daily lives, their traditions, and how they deal with the lords and pirates among them. It could also show how they interact with the other kingdoms during times of peace and war.
If the spin - off is about the Targaryen dynasty, then characters like Aegon the Conqueror could be the main character. He was the one who led the Targaryen invasion of Westeros with his sisters and their dragons. His story is full of conquest, power - building, and family drama.
One main character could be a genetically - enhanced human who has special abilities, like Arya Stark's skills in the original. She could be on a mission to avenge her family who were killed by a powerful space - faring clan. There could also be a powerful warlord from a distant star system, a bit like Ramsay Bolton, feared for his cruelty and thirst for power. The interactions between these diverse characters would drive the story forward in this space - based Game of Thrones fanfiction.
Arya Stark could be a main character. She could use her skills as a Faceless Man to infiltrate the enemy's camp before a big battle and gather intelligence. Her ability to change her appearance would give her an edge in spying and sabotage operations during the battle.
It could be Arya Stark as the bodyguard. Given her skills in combat and disguise, she would make a great protector. She could be protecting someone like Bran Stark as he continues to develop his powers and is a target because of his abilities.
The children of the original characters would be likely main characters. For example, Jon Snow's (if he has any) descendants. They could inherit his sense of honor and face new challenges in the post - war Westeros.
You could have a main character who is a commoner. Maybe a peasant girl who witnesses the fall of a great house and has to navigate the chaos that follows. She could get involved with the various factions vying for power, and through her eyes, we see the events of the prequel unfold. This would give a different perspective compared to the noble - centered stories we often see in the 'Game of Thrones' universe.
Gendry could also play a major role. As a skilled blacksmith and a bastard like Jon, he has the strength and the will to fight for change. He could use his skills to arm the revolutionaries and his knowledge of the common people's plight to inspire them to rise up against the unjust noble rule.
A samurai - like character from Zipang could be a main character. They would be skilled in combat and bound by a strict code of honor. They could enter the fray in Westeros and become involved in the power struggles, perhaps even challenging the likes of Jaime Lannister in a duel of honor.
Jon Snow would also make a great main character. He could be on a mission to unite the different houses' spaceships against a common threat, like an alien race or a powerful space - faring pirate group. His leadership skills and sense of justice would be put to the test in this new setting.