The mother's new partner. He doesn't want the forgotten daughter to be part of the family as he fears she will disrupt the new family dynamic he has been trying to build. He might use various means to keep her away from the family.
Maybe it's an evil organization that wants to isolate Naruto. By making his family forget him, they hope to break Naruto's spirit and prevent him from becoming a powerful force in the ninja world. So they target his family's memories as a way to get to him.
The main antagonist could be an ancient demigod who was forgotten by history but has now awakened. This demigod could be bitter about being forgotten and decides to take revenge on the current demigod world. He might have some dark and powerful magic that he's been developing during his long slumber.
A group of rogue demigods could be the main antagonists. They might be jealous of the attention the daughter gets because of her parents. So, they plot to make her life difficult and try to drive a wedge between her and the other demigods.
Maybe an organization that wants to use her unique abilities. If she has inherited some special power from Kakashi or has her own distinct skills, an evil organization could try to capture her and force her to work for them. They would be the main obstacle she has to face in the story.
It could be a powerful vampire from a different coven. Maybe one who sees the daughter of war as a threat to their power or territory in the Twilight world.
Another option is a power - hungry wizard from within the Ministry of Magic. They might see Harry's daughter as a tool to gain more power. They could try to manipulate her or create situations where she is framed for things she didn't do, all in an attempt to control her and use her connection to Harry for their own political gain.
There could also be a group of rogue demigods who oppose the daughter of Artemis. They might be jealous of her powers or her connection to Artemis. They could try to sabotage her and Percy's quests and cause trouble for them at every turn.
It could be an old enemy of Percy and Annabeth. Maybe a monster that they thought they had defeated long ago but has come back for revenge. This time, it might target Annabeth's daughter to get back at them.
It could be Voldemort. Since he is the main bad guy in the Harry Potter series, it would make sense for him to be the antagonist. He might see the daughter of Thor as a threat to his plans of taking over the wizarding world.
Another possibility is that the antagonist could be a dark - side version of Naruto himself. The discovery of the forgotten bloodline could stir some dark desires within him. This internal struggle could be personified as a separate entity that tries to take over Naruto and use the power of the bloodline for evil. Naruto would then have to fight against this internal darkness as well as external threats who are also interested in his new - found power.