The Akatsuki could be potential enemies. They are always on the lookout for strong ninja to either recruit or eliminate. Since Kakashi is a well - known and powerful ninja, his little brother might draw their attention. They could see him as a potential threat or a valuable asset.
Some rogue ninja from other villages might target him. If word gets out that he is Kakashi's little brother, they might think that by capturing or killing him, they can get revenge on Kakashi or use him as a bargaining chip. For example, ninja from a village that Kakashi had defeated in a previous battle might seek to harm his little brother.
The Akatsuki could be potential enemies. They might see Naruto's little sister as a way to get to Naruto. Maybe they think they can use her as a hostage or extract some information from her about Naruto or the Nine - Tails. Another enemy could be some of the rogue ninja who are after the bounty on Naruto's head and see his sister as an easy target to get to him.
Perhaps the fanfiction could focus on a mission where Kakashi's little brother has to prove himself. He could be part of a team that is in a dangerous situation, and he has to use his unique skills, which might be different from Kakashi's. For example, while Kakashi is known for his Sharingan and lightning - style jutsu, his brother could be more proficient in genjutsu or some other form of combat.
A group of bandits who operate near the village could also be enemies. They might target Naruto Jade's dad because he is a threat to their illegal activities. They could try to ambush him or attack the village to get to him.
The First Order could still be a threat. They might see her as a symbol of the Resistance and try to eliminate her. Or it could be a new Sith cult that has risen in the ashes of the old Sith order.
There could be a new dark wizard or witch who is jealous of the Potter family's legacy. They might target Harry Potter's daughter to try and bring down the family name and prove their own power.
The remnants of Voldemort's followers could still be a threat. They might see the third child as a symbol of the new hope in the wizarding world that they want to destroy. Maybe they believe that the child has some sort of power that could ultimately be used to completely wipe out their dark ideology, so they target the child.
For allies, All Might could be an interesting choice even when they are babies. All Might might sense Izuku's potential and also see that Shigaraki could be redeemed if guided right. Another potential ally could be Aizawa. He could be the one who trains them in basic self - defense skills when they are kids. As for enemies, the League of Villains could be a problem for Izuku, as they might see him as a threat to their plans with Shigaraki. Also, some of the more evil - minded heroes who don't believe in second chances for villains like Shigaraki could be enemies.
Voldemort's remaining followers could be her enemies. They might be planning something new and Hermione, as a spy, would be trying to stop them. Also, some corrupt Ministry of Magic officials who are up to no good. They would see Hermione as a threat to their secret operations.
The Death Eaters could still be a major threat. Even with Voldemort gone, some of them might be trying to revive the dark ways and see the wizard king as a big obstacle in their path.
The children of Ares might see Percy as a threat. Since Cupid represents love and Ares represents war, their natures are quite opposite. The Ares kids could be jealous of Percy's powers or simply not trust him because of his different lineage.