A plot could be centered around Zuko from Avatar joining the Straw Hats for a while. He could teach Sanji some fire - bending inspired cooking techniques. Meanwhile, Nami might use her knowledge of weather to help the Avatar characters understand their own natural elements better. And Usopp could create some cool gadgets inspired by the technology and bending in the Avatar world.
One idea could be that the Straw Hats end up in the Naruto world somehow. Maybe Luffy and Naruto meet and instantly become friends because of their similar positive and determined personalities. They could team up to fight a common enemy like Akainu who has somehow also entered the Naruto world and is causing chaos. Another plot could be that the Devil Fruits from One Piece start to appear in the Naruto world, and ninja start to use them in combination with their jutsu, creating new and powerful abilities.
Perhaps in this crossover, the Akatsuki from Naruto are after a Devil Fruit in the One Piece world. Naruto and his friends team up with the Straw Hat Pirates to protect it. Along the way, there would be a lot of cultural clashes and misunderstandings that lead to both comical and heartwarming moments. For example, Sasuke might initially not trust the pirates but then come to respect them as they fight side by side.
One idea could be that Naruto and his friends somehow end up in the One Piece world. Naruto's ninja skills like shadow clones could be really useful in pirate battles. For example, he could use the clones to confuse the enemy pirates while Luffy and his crew attack. Another idea is that the Devil Fruits in One Piece could be incorporated into the Naruto universe. Maybe some ninjas start to eat Devil Fruits and gain new powers, which would create a whole new dynamic in the ninja world.
Perhaps there is a crossover of the worlds where the Hollows start attacking the One Piece islands because they sense a large amount of spiritual energy there. The Soul Reapers follow them and have to work with the local pirates, including the Straw Hats, to defend the islands. In the process, characters from both series learn about each other's powers and cultures. Luffy might be intrigued by Ichigo's ability to transform into different forms, and Ichigo could be amazed by Luffy's stretching powers.
One idea could be that Whitebeard is transported to a different time in the One Piece world. Maybe he ends up in the future and has to deal with new pirates and powers that he's never seen before. Another could be a crossover with another anime world, like he somehow gets stuck in the Naruto world and has to find his way back while dealing with ninjas.
Perhaps a villain from DBZ, like Frieza, finds a way to travel to the One Piece universe. He starts enslaving the pirates and taking over islands. Luffy and his crew would be the first to resist, but they quickly realize they need help. Goku and Vegeta then arrive and have to teach the pirates about ki and how to fight against Frieza's powerful minions. It would be a great opportunity to see the different fighting styles blend together.
One idea could be Mihawk getting transported to a different part of the One Piece world where he has to team up with the Straw Hats to face a new and powerful enemy. Maybe a group of ancient sea gods that are awakened and threatening to destroy all pirates. The Straw Hats could initially be wary of Mihawk but soon realize his skills are crucial for their survival.
One idea could be Ace crossing over into a modern - day world where he has to adapt to new technologies while still having his devil fruit powers. He might get involved in some sort of street racing using his fire powers to boost his vehicle.
One idea could be that the characters from Khr end up in the One Piece world and have to navigate the Grand Line. They might join a pirate crew and use their unique powers from Khr in battles against other pirates or the Marines. Another plot could involve a Devil Fruit user from One Piece ending up in the Khr world and causing chaos with their powers there.
A cool plot could involve the Pokemon world's Team Rocket equivalents trying to steal the One Piece. They might think it's some sort of ultimate Pokemon - related power source. Meanwhile, the Pokemon trainers in the One Piece world could form alliances with the pirates. For example, a water - type Pokemon trainer could team up with Sanji on a ship, using their Pokemon's water abilities to help with cooking and other ship - related tasks.