A possible plotline could be that they made a childhood promise to always protect each other's families. When Itachi is faced with the decision to kill his clan, Sakura tries to stop him, not fully understanding the situation at first. This creates a rift between them, but later, as Sakura learns the truth, she tries to help Itachi in her own way, like protecting Sasuke from the shadows as Itachi had asked her to in a moment of desperation.
Well, perhaps Itachi is under the influence of a genjutsu himself when he captures Sakura. He could be acting against his own will. Sakura, in this situation, might try to break the genjutsu on Itachi while also trying to free herself. And during this time, she could discover some secrets about Itachi's past or his true motives that were hidden before. This could lead to a complex relationship between them where Sakura has a new perspective on Itachi, not just as an enemy but as a victim too.
One possible plot could be Itachi and Sakura bonding over their love for medicine. Sakura is a talented medical ninja, and Itachi has knowledge of various herbs and healing techniques from his clan. They could start sharing their knowledge, and Sakura could learn some unique Uchiha healing methods from Itachi. This would not only strengthen their friendship but also help Sakura become an even better medic. As their friendship grows, they might face challenges together, like having to deal with rogue ninjas who are after Itachi's Sharingan or Sakura's medical knowledge.
Perhaps there could be a plot where Naruto and Tenten discover a new form of training. They accidentally stumble upon a hidden area in the forest where the chakra flow is different. Together, they figure out how to use this new environment to enhance their skills. Naruto might learn some precision from Tenten while she could gain some of his tenacity when it comes to training.
Maybe they meet when they are very young. Naruto, being an outcast in his village, and Rias, who might be facing some politics in her devil world. They bond over their shared feelings of loneliness and not being fully understood. As they grow up, they help each other out. For example, when Naruto has to face powerful enemies in the Chunin Exams, Rias could use her devil powers secretly to assist him without getting caught.
One possible plotline could be Kakashi trying to protect Sakura at all costs. He might follow her around secretly to keep her safe from any potential threats in the ninja world. Another could be that he becomes overly concerned with her training, pushing her to her limits in a way that no one else does, all because of his obsession.
One possible plotline could be that Sasuke, feeling conflicted by his past and the secrets he holds, distances himself from Sakura and starts to develop an inappropriate emotional connection with someone else, which Sakura misinterprets as cheating. As for Itachi's role, perhaps his memories or the influence he had on Sasuke play into Sasuke's actions, like Sasuke trying to live up to some ideal Itachi had that made him question his relationship with Sakura.
One possible plotline could be that Itachi and Shisui, being the skilled Uchiha they are, take Sakura under their wing to train her in some unique jutsu. Maybe they see her potential and want to help her reach a new level of power. For example, Shisui could teach her his body - flicker technique while Itachi imparts some of his knowledge about genjutsu. This would create an interesting dynamic as Sakura tries to adapt to their different teaching styles.
One possible plotline could be that Sakura discovers a new type of lemonade that has some sort of magical property. Itachi, being a powerful and mysterious figure, is interested in this lemonade for some reason related to his own goals or the well - being of his clan. Sakura, initially hesitant, decides to team up with Itachi to explore the secrets of the lemonade further. Maybe they find out that the lemonade can heal certain dark chakra - related ailments that are plaguing Itachi's clan.
Well, in a fanfic like this, the plot could revolve around Sasori's obsession leading to him creating puppets in Sakura's likeness. He might be so fixated on her that he tries to replicate her in his own art form. Or perhaps he tries to manipulate situations in the ninja world to get Sakura to come to him willingly. He could send out false threats or create chaos just to draw her attention. And as Sakura becomes aware of his obsession, she has to figure out how to deal with it, whether it's through fighting or trying to understand the root of his feelings.
Well, their friendship could potentially change Sasuke's path. Since Sakura is friends with Itachi, she might be able to communicate better with Sasuke about his brother. For example, she could tell Sasuke about the good side of Itachi that he never knew, which could make Sasuke less vengeful and more focused on rebuilding his clan. This would be a huge shift from the original storyline where Sasuke is mainly driven by revenge against Itachi.