It could be an ancient Digimon that was sealed away long ago in both the Tamers' world and the Fusion world. Due to some unforeseen events in the fanfiction, it gets released. This Digimon is extremely powerful and has a grudge against all living Digimon. It wants to destroy both worlds and start anew, so it becomes the main threat that the Tamers and Fusion Digimon must face together.
A powerful and mysterious Digimon that has the ability to absorb the powers of both Tamers' Digimon and Fusion Digimon could be the main antagonist. It might be seeking to create a new world order where it rules over all Digimon.
Well, perhaps in the fanfiction, a powerful Digimon from the Tamers universe gets corrupted and starts causing chaos in the Fusion world. The Fusion Digimon are initially suspicious of the Tamers but then realize they need to work together to stop this corrupted Digimon. The Tamers and their Digimon have to learn new strategies to deal with the unique challenges of the Fusion world.
One idea could be that the Tamers from Digimon Tamers end up in the world of Digimon Fusion by some sort of digital rift. Their Digimon might have to adapt to the new rules and Digimon forms in the Fusion world. For example, Guilmon could be intrigued by the more complex fusions he sees and try to find a way to participate in a fusion himself.
For the characters from Digimon Tamers, they could start off being a bit out of place in the Fusion world. Takato, for example, being the creative and kind - hearted Tamer he is, might initially be a bit shy around the more aggressive Digimon in the Fusion world. But as he experiences more, he could become more assertive. His Guilmon would also grow, learning from the more battle - hardened Digimon in the Fusion world and becoming more confident in combat.
Perhaps in the 'Digimon Tamers meet Digidestined' fanfiction, the characters would exchange their experiences. The Digidestined could share how they first discovered their Digivices and the early days of their adventures. The Tamers, on the other hand, might talk about their more technological approach to Digimon. They could also start to compare and contrast the different types of Digimon evolution in their respective universes, leading to some interesting discussions and new ideas about Digimon growth and power.
It could be a powerful warlock who has found a way to manipulate time and space. He wants to stop Paige and Prue from joining forces because he fears their combined power. So he creates various obstacles and illusions to keep them apart.
Maybe a powerful rogue ninja who has discovered a way to steal the powers of divine entities. He sets his sights on Amaterasu and Naruto because he knows that if he can combine their powers, he will be unstoppable. He creates various traps and illusions to separate them and weaken them so that he can carry out his evil plan.
A powerful new pirate group could be the main antagonist. They might be after the same treasure or territory as Luffy and Shanks. They could have some unique and dangerous abilities, like the ability to control sea monsters. Their leader could be a former crewmate of a well - known and feared pirate, who has his own vendetta against both Luffy and Shanks for some past reasons.
There could be an ancient force that is awakened by the meeting of Harry and Hela. This force wants to destroy both of them because their combined powers could potentially stop it from achieving its goal of spreading chaos and destruction throughout all the realms. It would use all kinds of devious means to try and separate them and defeat them one by one.
Maybe a powerful warlord from Negan's world who somehow follows him into Artemis' realm. This warlord, with his own thirst for power and destruction, would oppose both Negan (if he starts to side with Artemis) and Artemis herself, wanting to take over the new world he has found.
It could be another god who is jealous of Zeus' interest in Atreus. Maybe a god who feels that Atreus is an outsider and doesn't belong in their divine affairs.